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Apple's MacBook Air line is fantastic for basic productivity work. I own a MacBook Air and I've never found myself longing for a Pro—it's an amazing laptop. If you've been looking to buy one, I have some good news for you—they are now cheaper, and they now have Apple's latest M4 chips.

SAVE $100: As of March 5, get the Google Pixel 8a for $399 at Amazon, which is $100 off its normal price of $499. That's a 20% discount.

Opens in a new window Credit: Amazon Google Pixel 8a $399 at Amazon
$499 Save $100 Get Deal

For anyone buying a new smartphone, a new iPhone or the latest Samsung option might be alluring. But if you can't bring yourself to spend an arm and a leg for the newest model, you still have other phones out there to choose from. The Google Pixel 8a, for example, is one such smartphone that's well worth the price — and it's even on sale right now.

As of March 5, get the Google Pixel 8a for just $399 at Amazon. That's $100 off its usual price of $499, and a discount of 20%. You can choose from four colors: Aloe, Bay, Obsidian, and Porcelain.

SEE ALSO: Samsung has phone concepts that bend, stretch and fold in every possible way

The Google Pixel 8a has a crisp 6.1-inch Actua display with 2400x1080 resolution and a 120Hz adaptive refresh rate. Under the hood, you can expect to find a Google Tensor G3 processor, 128GB of storage, and 8GB of RAM. It also includes several AI features, the same that came with the Pixel 8, including Circle to Search, AI call screening, Magic Editor, and more.

Mashable's Alex Perry appreciated the phone's "elite performance coupled with a flagship-esque display and decent enough camera specs are more than enough to make up for some lackluster returning AI features."

There's plenty to keep you busy with on the Pixel 8a, and most importantly, it'll keep additional cash in your pocket for the time being, which we can all agree is a great thing.

Online, the citizens of America are uniting — not for peace, not for progress, not to defend itself, but for a Vice President who is edited to look like a Gerber baby.

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It's hard to pinpoint an exact starting point for the JD Vance babyface edits, but Know Your Meme attributes it to X user @DaveMcNamee3000, who posted an edited photo of Vance with a rounder face and larger cheeks on Oct. 2, 2024.

"For every 100 likes I will turn JD Vance into a progressively apple-cheeked baby," the user wrote, to the tune of thousands of reposts and hundreds of thousands of likes. Vance got babier. He got apple-cheekier. The internet joined in. The meme snowballed.

But it seems to have reached a fever pitch this week after Vance, on Feb. 28, asked Ukrainian President Volodymyr Zelenskyy if he had "said thank you once" during a meeting between them and President Donald Trump in front of the White House Press Pool. This, X users opined, does sound like something perhaps a baby would say; it is reminiscent of a child refusing to invite you to their birthday party; it is, at best, odd work for the Vice President of the United States.

The internet responded with an electric number of memes depicting the politician as a big, big, baby.

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Perhaps what is most remarkable about the trend isn't its oddity but its ability to bring both sides of the political spectrum together. Research from the Carnegie Endowment, for instance, shows that Americans are emotionally polarized, meaning they "harbor [a] strong dislike for members of the other party," an experience often attributed to social media.

But occasionally, social media can give us a bit of respite from that polarization. For instance, these baby-faced memes of Vice President JD Vance.

Making fun of the Republican Vice President might seem like the job for, well, not Republicans, but that's not exactly true. As one post on X pointed out, "Edited fatty JD Vance is the first meme template in a long while where I don’t know if the person sharing it is someone on the Left, or the most virulent Nazi you’ve ever met in your entire life. The entire political spectrum is enjoying these memes, it’s impossible to know."

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You might think, well, that's just one guy. And that might be true, but the top response is another user who wrote, "It's relatively easy to know, the left can't meme." (The left notoriously can, in fact, meme.) This obviously turned into an Internet Fight.

While not every conservative's post about JD Vance supports the meme, it is beautiful to see us all come together for one unifying cause: JD Vance with a big baby face.

SAVE $80: As of Mar. 5, get the Bose QuietComfort Ultra Earbuds for $219 at Amazon, down from their usual price of $299. That's a discount of 27%.

Opens in a new window Credit: Amazon Bose QuietComfort Ultra Earbuds $219 at Amazon
$299 Save $80 Get Deal

Looking for a new pair of earbuds? Don't automatically assume AirPods are the only answer. You might want to give Bose's quality offerings a chance. The company knows audio and proves it consistently with its line of products that we have plenty of great things to say about at Mashable. Case in point: the Bose QuietComfort Ultra Earbuds, which are on sale today.

As of March 5, get the Bose QuietComfort Ultra Earbuds for $219 at Amazon, down from their usual price of $299. That's a discount of 27%.

SEE ALSO: The Apple AirPods Pro 2 are my go-to earbuds — save $50 for a limited time

Mashable's Timothy Beck Werth had plenty of great things to say about these earbuds, awarding them a 4.6 out of 5 in his review. He praised their "excellent noise cancellation," "very cool" immersive 3D audio tech, and "long battery life," giving them the Mashable Choice Award for their performance.

These earbuds offer deep, satisfying bass and crisp treble, with spatial audio support that puts you right in the middle of the action. Plus, their CustomTune tech adapts to your ears and gives you active noise cancellation tailored to your ears. Change out your earbuds with the nine additional eartips and swap between three listening modes, with up to 6 hours of listening time per charge.

Whether you want a new pair of earbuds for a serious upgrade or you just need something a little different, this is a great option that you don't want to pass up now that they're available at a discount.

YouTube is expanding its YouTube Premium Lite subscription service, which gives you ad-fre YouTube but without the added YouTube Music service and other features. It started in Thailand, Germany, and Australia, and now it's available in the United States and will come to other countries soon.

TL;DR: Live stream Guadalajara vs. Club America in the Concacaf Champions Cup for free on YouTube. Access this free live stream from anywhere in the world with ExpressVPN.

There are a number of interesting matchups in the latest Concacaf Champions Cup knockout round, but nothing comes close to Guadalajara vs. Club America. El Súper Clásico is coming to the Concacaf Champions Cup, and we couldn't be happier about it. We're expecting fireworks from this famous game.

If you want to watch Guadalajara vs. Club America in the Concacaf Champions Cup for free from anywhere in the world, we have all the information you need.

When is Guadalajara vs. Club America?

Guadalajara vs. Club America in the Concacaf Champions Cup kicks off at 8:30 p.m. ET on March 5. This fixture takes place at the Akron Stadium.

How to watch Guadalajara vs. Club America for free

Guadalajara vs. Club America in the Concacaf Champions Cup is available to live stream for free on YouTube.

This free live stream is available in most locations around the world, but not in North or Central America. Fortunately, fans in these excluded territories can still access this free live stream with a VPN. These tools can hide your real IP address (digital location) and connect you to a secure server in the UK (or somewhere else with access), meaning you can unblock free live streams of the Concacaf Champions Cup from anywhere in the world.

Live stream Guadalajara vs. Club America by following these simple steps:

1. Subscribe to a streaming-friendly VPN (like ExpressVPN)

2. Download the app to your device of choice (the best VPNs have apps for Windows, Mac, iOS, Android, Linux, and more)

3. Open up the app and connect to a server in the UK (or somewhere else with access)

4. Visit YouTube

5. Live stream Guadalajara vs. Club America for free

Opens in a new window Credit: ExpressVPN ExpressVPN (1-Year Subscription + 3 Months Free) $99.95 only at ExpressVPN (with money-back guarantee) Get Deal

The best VPNs for streaming are not free, but most do offer free-trials or money-back guarantees. By leveraging these offers, you can watch Guadalajara vs. Club America in the Concacaf Champions Cup without actually spending anything. This clearly isn't a long-term solution, but it does give you enough time to stream select Concacaf Champions Cup fixtures before recovering your investment.

If you want to retain permanent access to free streaming services from around the world, you'll need a subscription. Fortunately, the best VPN for streaming live sport is on sale for a limited time.

What is the best VPN for YouTube?

ExpressVPN is the best choice for bypassing geo-restrictions to stream live sport on YouTube, for a number of reasons:

• Servers in 105 countries including the UK

• Easy-to-use app available on all major devices including iPhone, Android, Windows, Mac, and more

• Strict no-logging policy so your data is secure

• Fast connection speeds free from throttling

• Up to eight simultaneous connections

• 30-day money-back guarantee

A one-year subscription to ExpressVPN is on sale for $99.95 and includes an extra three months for free — 49% off for a limited time. This plan also includes a year of free unlimited cloud backup and a generous 30-day money-back guarantee.

Live stream Guadalajara vs. Club America in the Concacaf Champions Cup for free with ExpressVPN.

TL;DR: Live stream Bayern Munich vs. Leverkusen in the Champions League for free on Virgin Media Player. Access this free streaming platform from anywhere in the world with ExpressVPN.

There are so many interesting matchups in the first round of Champions League knockout fixtures, including Bayern Munich vs. Leverkusen. Celtic came close to knocking out Bayern Munich in the playoff round, but Vincent Kompany's side survived to earn a chance to face off against their domestic rivals.

If you want to watch Bayern Munich vs. Leverkusen in the Champions League from anywhere in the world, we have all the information you need.

When is Bayern Munich vs. Leverkusen?

Bayern Munich vs. Leverkusen in the Champions League kicks off at 8 p.m. GMT on March 5. This fixture takes place at the Allianz Arena.

How to watch Bayern Munich vs. Leverkusen for free

Bayern Munich vs. Leverkusen is available to live stream for free on Virgin Media Player.

Virgin Media Player is geo-restricted to Ireland, but anyone can access this free streaming platform with a VPN. These tools can hide your real IP address (digital location) and connect you to a secure server in Ireland, meaning you can unblock Virgin Media Player to stream the Champions League for free from anywhere in the world.

Live stream Bayern Munich vs. Leverkusen for free by following these simple steps:

1. Subscribe to a streaming-friendly VPN (like ExpressVPN)

2. Download the app to your device of choice (the best VPNs have apps for Windows, Mac, iOS, Android, Linux, and more)

3. Open up the app and connect to a server in Ireland

4. Visit Virgin Media Player

5. Watch Bayern Munich vs. Leverkusen for free from anywhere in the world

Opens in a new window Credit: ExpressVPN ExpressVPN (1-Year Subscription + 3 Months Free) $99.95 only at ExpressVPN (with money-back guarantee) Get Deal

The best VPNs for streaming are not free, but most do offer free-trials or money-back guarantees. By leveraging these offers, you can access free live streams of the Champions League without actually spending anything. This obviously isn't a long-term solution, but it does give you enough time to stream Bayern Munich vs. Leverkusen (plus more Champions League fixtures) before recovering your investment.

What is the best VPN for Virgin Media Player?

ExpressVPN is the best choice for bypassing geo-restrictions to stream live sport on Virgin Media Player, for a number of reasons:

• Servers in 105 countries including Ireland

• Easy-to-use app available on all major devices including iPhone, Android, Windows, Mac, and more

• Strict no-logging policy so your data is secure

• Fast connection speeds free from throttling

• Up to eight simultaneous connections

• 30-day money-back guarantee

A one-year subscription to ExpressVPN is on sale for $99.95 and includes an extra three months for free — 49% off for a limited time. This plan includes a year of free unlimited cloud backup and a generous 30-day money-back guarantee.

Live stream Bayern Munich vs. Leverkusen in the Champions League for free with ExpressVPN.

TL;DR: Live stream PSG vs. Liverpool in the Champions League for free on RTÉ Player. Access this free streaming platform from anywhere in the world with ExpressVPN.

The Champions League playoff round produced some really tense matchups, with late goals deciding the result. That was not the case with PSG vs. Brest. The French champions won the second leg 7-0 to secure a 10-0 aggregate victory. That's about as easy as it gets.

It's probably not going to be that straightforward in the first knockout round, because PSG have been drawn against Liverpool in what is arguably the matchup of the round. Liverpool are flying domestically and in Europe this season. PSG will need to deliver an impressive performance to take anything from this game.

If you want to watch PSG vs. Liverpool in the Champions League for free from anywhere in the world, we have all the information you need.

When is PSG vs. Liverpool?

PSG vs. Liverpool in the Champions League kicks off at 8 p.m. GMT on March 5. This fixture takes place at the Parc des Princes.

How to watch PSG vs. Liverpool for free

PSG vs. Liverpool is available to live stream for free on RTÉ Player.

RTÉ Player is geo-restricted to Ireland, but anyone can access this free streaming service with a VPN. These tools can hide your real IP address (digital location) and connect you to a secure server in Ireland, meaning you can unblock free live streams of the Champions League from anywhere in the world.

Live stream PSG vs. Liverpool on RTÉ Player by following these simple steps:

1. Subscribe to a streaming-friendly VPN (like ExpressVPN)

2. Download the app to your device of choice (the best VPNs have apps for Windows, Mac, iOS, Android, Linux, and more)

3. Open up the app and connect to a server in Ireland

4. Sign in to RTÉ Player

5. Watch PSG vs. Liverpool for free from anywhere in the world

Opens in a new window Credit: ExpressVPN ExpressVPN (1-Year Subscription + 3 Months Free) $99.95 only at ExpressVPN (with money-back guarantee) Get Deal

The best VPNs for streaming are not free, but leading VPNs do tend to offer free-trial periods or money-back guarantees. By leveraging these offers, you can access free live streams of the Champions League without actually spending anything. This obviously isn't a long-term solution, but it does give you enough time to stream PSG vs. Liverpool (plus more Champions League fixtures) before recovering your investment.

What is the best VPN for RTÉ Player?

ExpressVPN is the best choice for bypassing geo-restrictions to stream live sport on RTÉ Player, for a number of reasons:

• Servers in 105 countries including Ireland

• Easy-to-use app available on all major devices including iPhone, Android, Windows, Mac, and more

• Strict no-logging policy so your data is secure

• Fast connection speeds free from throttling

• Up to eight simultaneous connections

• 30-day money-back guarantee

A one-year subscription to ExpressVPN is on sale for $99.95 and includes an extra three months for free — 49% off for a limited time. This plan includes a year of free unlimited cloud backup and a generous 30-day money-back guarantee.

Live stream PSG vs. Liverpool in the Champions League for free with ExpressVPN.

SAVE UP TO 55%: Several Tempur-Pedic sleep products are on sale at Amazon for up to 55% off, including mattress toppers, pillows, and sheet sets.

Best Tempur-Pedic deals at Amazon Best mattress topper deal Tempur-Adapt Supreme 3-inch memory foam mattress topper (queen) $198.49 (save $220.51) Get Deal Best Tempur-Pedic pillow deal Tempur-Pedic memory foam Symphony Pillow $53.99 (save $65.01) Get Deal Best Tempur-Pedic sheets deal Tempur ProAir sheet set (king, cool gray) $124.99 (save $144.01) Get Deal

Health and wellness hacks are all around us lately. We have supplements, apps, workout equipment, and more to keep us in tip-top shape and feeling good. But one of the simplest wellness hacks is sleep.

Getting a consistent good night's rest does wonders. Sleep is a great influencer in our overall mood, energy levels, and immune system function. Boiled down, it's worth investing in high-quality products that help you get a better night's sleep.

If your mattress, pillow, or sheets are proving to be uncomfortable, check out these Tempur-Pedic sale products at Amazon. Some offer up to 55% off. Here are some of our favorites.

Best Tempur-Pedic mattress topper deal Opens in a new window Credit: Tempur-Pedic Tempur-Adapt Supreme 3-inch memory foam mattress topper $198.49 at Amazon
$419 Save $220.51 Get Deal Why we like it

If you've been sleeping on a mattress that feels too firm and unsupportive, adding a plush mattress topper can completely transform the feel. The three-inch Tempur-Adapt topper is made with the brand's Tempur material which offers ideal support and pressure relief. In a queen size, the Tempur-Adapt mattress topper is on sale for just $198.49 at Amazon which works out to a 53% discount compared to the usual price of $419.

Tempur material is great for light sleepers who are easily disrupted if a partner rolls over or the dog jumps off the bed. It's designed to reduce motion transfer, giving you a better chance of a restorative sleep.

This mattress topper comes with a removable cover that you can clean in the washing machine, adding to the hygiene of your bedding setup. The cover itself is made with a soft, hypoallergenic material that can be great for sleepers with sensitive skin or allergies.

To keep the topper in place, Tempur-Pedic added corner straps, so you won't need to readjust the topper each morning.

Best Tempur-Pedic pillow deal Opens in a new window Credit: Tempur-Pedic Tempur-Pedic memory foam Symphony Pillow $53.99 at Amazon
$119 Save $65.01 Get Deal Why we like it

Can't remember the last time you got a new pillow? That could mean it's time for an upgrade. Designed with a luxury soft feel, the Tempur-Pedic memory foam Symphony Pillow could be perfect. It typically sells for $119, but today's deal at Amazon shaves 55% off that price, dropping it to just $53.99.

The pillow measures about five inches in height, and Tempur-Pedic mentions the dual-sided design is great for all sleeping positions. One side of the Symphony pillow is contoured for a flatter shape best suited for side or stomach sleepers. The other side offers contoured support, helping the neck, shoulders, and head.

The Tempur-Pedic Symphony pillow's removable cover is machine-washable and hypoallergenic.

Best Tempur-Pedic sheet set deal Opens in a new window Credit: Tempur-Pedic Tempur ProAir sheet set (king, cool gray) $124.99 at Amazon
$269 Save $144.01 Get Deal Why we like it

The Tempur ProAir sheets are made with cotton and Tencel Lyocell which makes these perfect for summer months or for those who tend to sleep hot. On the Tempur-Pedic site, a king-size set of the ProAir sheets sells for $269, but Amazon has them on sale today for just $124.99 in the cool gray colorway.

The ProAir sheets are designed to be light and breathable, giving a smooth and silky feel. While the material itself is moisture-wicking, it's also designed to be long-lasting. Tempur-Pedic added Stay Tight corner straps to the fitted sheet which makes it less likely to shift around or pop off. The set includes one fitted sheet, one flat sheet, and two pillow cases, so your bedding setup will be complete.

More Tempur-Pedic deals at Amazon:

• Tempur-Pedic Tempur-Ergo Neck Pillow (Large) — $66 $99 (save $33)

• Tempur ProAir Sheet Set (Azure, Twin) — $78.99 $199 (save $120.01)

• Tempur-Cloud 2-inch Mattress Topper (Queen) — $118.49 $219 (save $100.51)

After countless delays and one of the longest waits from Samsung in several years, the Android 15 (One UI 7) update for Galaxy devices is finally coming to your phones and tablets starting in April.

The Raspberry Pi 5 is a big step up in processing power, but it lacked support for the interlaced video output mode present on earlier models. Thankfully, that has now been fixed.

SAVE 25%: As of March 5, you can get the PuroAir HEPA Air Purifier for $149.99, down from $199, at Amazon. That's a savings of $49.01 and the lowest price we've seen on this model yet.

Opens in a new window Credit: PuroAir PuroAir HEPA Air Purifier $149.99 at Amazon
$199 Save $49.01 Get Deal

Although spring is a beautiful time of year, those colorful blooms can trigger everything from sneezing and itchy eyes to headaches and fatigue. One thing that might be able to save you from seasonal allergy misery is a high-quality HEPA air purifier.

Right now, you can get the PuroAir HEPA Air Purifier for $149.99 at Amazon. That’s a 25% discount and the cheapest price we’ve seen this model go for yet.

SEE ALSO: The best air purifiers for pet owners

The PuroAir can cover up to 1,000 square feet and filters up to 99.99% of pollutants, smoke, pollen, and dust. Its auto-detect function monitors indoor air quality and adjusts the fan to keep your home allergen-free. Reviewers also say it’s super quiet, which is good news for light sleepers.

The only caveat is that you’ll need to change the filter every three months or 90 days, but an indicator light reminds you when to swap it out.

The Mac Studio is Apple’s mid-range desktop Mac computer, between the entry-level Mac Mini and the high-power Mac Pro. Now, Apple has revealed new Mac Studio models with M4 Max and M3 Ultra chips, paired with Thunderbolt 5.

SAVE $25: As of March 5, you can get a 16-inch Canupdog digital photo frame for $104.99 at Amazon, down from $129.99. That's a savings of $25.

Opens in a new window Credit: Canupdog 16-inch Canupdog Digital Photo Frame $104.99 at Amazon
$129.99 Save $25.00 with on-screen coupon Get Deal

If you live in a smaller apartment and lack the physical space to create a gallery wall or show off your camera roll in frames, a digital photo frame is one way to put your memories on display. (It’s also a great way to make sure there aren’t any deductions on your security deposit when you move out.)

As of March 5, you can get the 16-inch Canupdog Digital Photo Frame for just $104.99 at Amazon. That’s a savings of $25. If you want a smaller frame, the 10-inch version is $71.99, or $28 off.

SEE ALSO: Grab a new Breville espresso maker for $200 off and make your perfect brew at home

The Canupdog 16-inch digital photo frame has a 1080p resolution, 32GB of storage capacity (that’s 100,000 photos’ worth of space), and comes with a two-year warranty, just in case. But the coolest thing about this frame is that you can instantly share photos and videos via the Uhale app. This makes it a great gift for grandparents or other family members because you can send them life updates in real-time.

The iPhone looks great in the dark mode, especially those with an OLED screen. However, for some reason, iOS doesn't consistently apply the dark theme to every visual element. Thankfully, you can fix that.

Introduction

Modern biomedical research is driven by the promise of precision medicine—tailored treatments for individual patients through the integration of diverse, large-scale datasets. Yet, the journey from raw data to actionable insights is fraught with challenges. Our team of researchers at Microsoft Research in the Health Futures group, in collaboration with the Perelman School of Medicine at the University of Pennsylvania (opens in new tab), conducted an in-depth exploration of these challenges in a study published in Nature Scientific Reports. The goal of this research was to identify pain points in the biomedical data lifecycle and offer actionable recommendations to enable secure data-sharing, improved interoperability, robust analysis, and foster collaboration across the biomedical research community.

Study at a glance

A deep understanding of the biomedical discovery process is crucial for advancing modern precision medicine initiatives. To explore this, our study involved in-depth, semi-structured interviews with biomedical research professionals spanning various roles including bench scientists, computational biologists, researchers, clinicians, and data curators. Participants provided detailed insights into their workflows, from data acquisition and curation to analysis and result dissemination. We used an inductive-deductive thematic analysis to identify key challenges occurring at each stage of the data lifecycle—from raw data collection to the communication of data-driven findings.

Some key challenges identified include:

• Data procurement and validation: Researchers struggle to identify and secure the right datasets for their research questions, often battling inconsistent quality and manual data validation.
• Computational hurdles: The integration of multiomic data requires navigating disparate computational environments and rapidly evolving toolsets, which can hinder reproducible analysis.
• Data distribution and collaboration: The absence of a unified data workflow and secure sharing infrastructure often leads to bottlenecks when coordinating between stakeholders across university labs, pharmaceutical companies, clinical settings, and third-party vendors.

Main takeaways and recommendations:

1. Establishing a unified biomedical data lifecycle 
   
   This study highlights the need for a unified process that spans all phases of the biomedical discovery process—from data-gathering and curation to analysis and dissemination. Such a data jobs-to-be-done framework would streamline standardized quality checks, reduce manual errors such as metadata reformatting, and ensure that the flow of data across different research phases remains secure and consistent. This harmonization is essential to accelerate research and build more robust, reproducible models that propel precision medicine forward.
2. Empowering stakeholder collaboration and secure data sharing 
   
   Effective biomedical discovery requires collaboration across multiple disciplines and institutions. A key takeaway from our interviews was the critical importance of collaboration and trust among stakeholders. Secure, user-friendly platforms that enable real-time data sharing and open communication among clinical trial managers, clinicians, computational scientists, and regulators can bridge the gap between isolated research silos. As a possible solution, by implementing centralized cloud-based infrastructures and democratizing data access, organizations can dramatically reduce data handoff issues and accelerate scientific discovery.
3. Adopting actionable recommendations to address data pain points 
   
   Based on the insights from this study, the authors propose a list of actionable recommendations such as:
   • Creating user-friendly platforms to transition from manual (bench-side) data collection to electronic systems.
   • Standardizing analysis workflows to facilitate reproducibility, including version control and the seamless integration of notebooks into larger workflows.
   • Leveraging emerging technologies such as generative AI and transformer models for automating data ingestion and processing of unstructured text.

If implemented, the recommendations from this study would help forge a reliable, scalable infrastructure for managing the complexity of biomedical data, ultimately advancing research and clinical outcomes.

Looking ahead

At Microsoft Research, we believe in the power of interdisciplinarity and innovation. This study not only identifies the critical pain points that have slowed biomedical discovery but also illustrates a clear path toward improved data integrity, interoperability, and collaboration. By uniting diverse stakeholders around a common, secure, and scalable data research lifecycle, we edge closer to realizing individualized therapeutics for every patient.

We encourage our colleagues, partners, and the broader research community to review the full study and consider these insights as key steps toward a more integrated biomedical data research infrastructure. The future of precision medicine depends on our ability to break down data silos and create a research data lifecycle that is both robust and responsive to the challenges of big data.

Explore the full paper (opens in new tab) in Nature Scientific Reports to see how these recommendations were derived, and consider how they might integrate into your work. Let’s reimagine biomedical discovery together—where every stakeholder contributes to a secure, interoperable, and innovative data ecosystem that transforms patient care.

We look forward to engaging with the community on these ideas as we continue to push the boundaries of biomedical discovery at Microsoft Research.

Access the full paper Opens in a new tab

The post Advancing biomedical discovery: Overcoming data challenges in precision medicine appeared first on Microsoft Research.

Check out the best Amazon deals of the day as of March 5: OUR TOP PICK Shark SpeedStyle hair dryer $159.99 (save $40 + get $8 Amazon credit) Get Deal BEST CAMERA DEAL DJI Osmo Action 4 $209.99 (save $79.01) Get Deal BEST HEADPHONES DEAL Soundcore Space Q45 headphones $99.99 (save $50) Get Deal BEST POWER BANK DEAL Anker Zolo Power Bank $12.94 (save $13.05) Get Deal BEST STREAMING DEVICE DEAL Amazon Fire TV Cube $109.99 (save $30) Get Deal

Celebrate being halfway to the weekend with another handpicked set of deals at Amazon. Whether you're an Amazon device admirer, love a good Dyson dupe, or are just looking to score some savings on top tech in general, we've got a deal for you. Happy hump day.

Here are our picks for the best Amazon deals of the day on March 5. If none of these are your cup of tea, be sure to check out our picks from March 3 and 4. Many of those are still live, including a Google Pixel 9 and Apple M4 iPad Pro at its best price ever.

Our top pick: Shark SpeedStyle Opens in a new window Credit: Shark Shark SpeedStyle hair dryer for straight and wavy hair $159.99 at Amazon
$199.99 Save $40 get $8 Amazon credit Get Deal

If you've had your eye on the Dyson Supersonic, but can't fathom spending over $400 on a hair dryer, check out the Shark SpeedStyle. The Shark dryer is also designed to give you salon-quality blowouts without the heat damage. It offers four heat and three airflow settings, includes a handful of attachments for customization, is light as a feather, and regulates temperature 1,000 times per second. This particular model is built for straight and wavy hair, so it includes the QuickSmooth Brush, RapidGloss Finisher, and Turbo Concentrator attachments. As of March 5, it's on sale for just $159.99 at Amazon. That's 20% off its usual cost and the lowest price in over a month. Plus, for a limited time, you'll get an $8 Amazon credit automatically added to your account after purchase.

DJI Osmo Action 4 Opens in a new window Credit: DJI DJI Osmo Action 4 $209.99 at Amazon
$289 Save $79.01 Get Deal

"The DJI Osmo Action 4 makes a good argument for buying an action camera that's not a GoPro," our friends at PCMag (also owned by Ziff Davis) write in their review. It's built to withstand the elements (freeze resistant, waterproof up to 159ft), has a clean interface, lasts up to 2.5 hours on a charge, and has excellent low-light performance and digital stabilization. It would suit content creation and vlogging better than action sports, but is still solid for all sorts of adventures. It's usually $289, but as of March 5, it's on sale for just $209.99 — that's 27% in savings and its lowest price on record.

Soundcore Space Q45 Opens in a new window Credit: Anker Soundcore Space Q45 $99.99 at Amazon
$149.99 Save $50.00 Get Deal

Anker's Soundcore Space Q45 noise-cancelling headphones may not be the fanciest on the market, but they're a worthy option that won't cost a small fortune. Our sister site PCMag called them a "budget-friendly Bose competitor" and credited their solid audio quality, decent noise cancellation, and reasonable price for their rating. The adaptive noise-cancelling feature is customizable with five unique levels and the battery delivers up to 50 hours of audio with ANC turned on. Usually $149.99, you can snag a pair at Amazon for only $99.99 as of March 5. That's 33% in savings.

Anker Zolo Power Bank Opens in a new window Credit: Anker Anker Zolo power bank $12.94 at Amazon
$25.99 Save $13.05 Get Deal

The Anker Zolo power bank is a fabulous companion for any type of trip. It packs a built-in USB-C cable to juice up newer phones and devices, as well as USB-C and USB-A ports to plug in charging cables for other devices. And thanks to 30W two-way fast-charging, it won't take a million years to bring your device back to life like other power banks. While it's usually pretty affordable at $25.99, it's a total steal as of March 5 at just $12.94. That's 50% in savings.

Amazon Fire TV Cube Opens in a new window Credit: Amazon Amazon Fire TV Cube $109.99 at Amazon
$139.99 Save $30.00 Get Deal

Part speedy streaming device, part Alexa-enabled speaker, the Amazon Fire TV Cube is one of the most feature-packed media streamers on the market. You can use it as you would a smart speaker — check the weather, control your smart home devices, set timers, etc. — as well as navigating all of your favorite streaming apps in one place. It's the only Fire TV streaming device to offer hands-free voice commands. It's also equipped with WiFi 6E, HDMI pass-through, a speedy 2.0Ghz processor, and 4K and Dolby Atmos support. It's usually $139.99, but you can save 21% at Amazon as of March 5 and grab it for $109.99.

None of these deals catching your eye? Check out Amazon's daily deals for even more savings.

UPDATE: Mar. 5, 2025, 11:25 a.m. EST This story has been updated with additional spec details.

Everywhere you can preorder the new Apple Mac Studio: The Apple Store Apple Mac Studio (M4 Max) Starting at $1,999 Pre-Order Here The Apple Store Apple Mac Studio (M3 Ultra) Starting at $3,999 Pre-Order Here

Apple surprise-announced a new Mac Studio featuring the M4 Max and all-new M3 Ultra chips in the middle of its "Air" week Wednesday. Set for release on March 12, the refreshed compact desktop is now available for preorder in the Apple Store starting at $1,999 for the M4 Max version and $3,999 for the M3 Ultra variant.

Billed as "the most powerful Mac ever" in Apple's press release, the new Mac Studio will supposedly deliver "a big boost in performance compared to the previous generation, and a massive leap for users coming from older Macs."

The M4 Max model has up to a 16-core CPU and up to a 40-core GPU, making it up to 3.5 times faster than the M1 Max-powered Mac Studio from late 2021 and up to 6.1 times faster than a 27-inch Intel iMac from 2020. Its 16-core Neural Engine is supposedly three times faster than its M1 Max counterpart. It comes with 32GB to 128GB of RAM and 512GB to 8TB of SSD storage, maxing out at $5,899, and it supports up to five displays. Apple recommends it for creative professionals, developers, and engineers with heavy workflows involving visuals and AI tasks.

SEE ALSO: Here's what you need to know about preordering the new M4 Apple MacBook Air

The M3 Ultra model is geared toward users with workloads that are somehow even more demanding. With up to a 32-core CPU (including 24 performance cores), the most CPU cores Apple's even crammed into a Mac, it's up to twice as fast as the M4 Max version in certain tasks and up to 2.6 times faster than the M1 Ultra Mac Studio from 2022. That CPU is joined by up to an 80-core GPU, another record-setter, plus a 32-core Neural Engine for AI tasks and machine learning. It comes with 96GB to 512GB of RAM and 1TB to 16TB of storage, maxing out at an eye-watering $14,099. It supports up to eight 6K displays.

Both configurations' GPUs feature dynamic caching, hardware-accelerated mesh shading, and a second-generation ray-tracing engine "for more seamless content creation and gaming," according to Apple.

On the outside, the new Mac Studio is the same silver box we've come to know, except it now has Thunderbolt 5 connectivity. There are four Thunderbolt 5 ports on the back of both configurations alongside two USB-A ports, an HDMI port, a 10Gb Ethernet port, and a headphone jack. Both models have an SDXC card slot on the front, which the M3 Ultra model pairs with two extra Thunderbolt 5 ports. The M4 Max model swaps them for two USB-C ports.

SAVE $170: The Best Buy Drops deal for March 5 is the Ninja Woodfire Outdoor Grill & Smoker for $199.99, down from the usual price of $369.99. That works out to a 46% discount when you buy it through the Best Buy app.

Opens in a new window Credit: Ninja Ninja Woodfire Outdoor Grill & Smoker $199.99 at Best Buy
$369.99 Save $170 via the Best Buy app Get Deal

Cooking outdoors in the summer is one of life's simple pleasures. Fill your plate with grilled ribs, chicken, or steak and don't forget those perfect summer vegetables. If your outdoor cooking setup could use an upgrade before we hit the summer season, Best Buy has a great deal in store.

The Best Buy Drops deals for March 5 is the Ninja Woodfire Outdoor Grill & Smoker, on sale for just $199.99 instead of the usual price of $369.99. That's a 46% discount that saves you $170. To grab this grill and smoker at the sale price, you'll need to head into the Best Buy app on your smartphone and be logged in to a My Best Buy account, which is free to join.

Keep in mind that Best Buy Drops only last for one day and they tend to sell out, so hop on this deal quickly if you're interested.

The versatile Ninja Woodfire Outdoor Grill & Smoker has seven cooking functions in the one unit: grill, smoker, air crisp, bake, roast, broil, and dehydrate. That means you can take your kitchen tasks outside for the summer and perfectly grill steak, roast vegetables, bake cornbread, and air fry wings, all with the same appliance.

SEE ALSO: Snag a refurbished Ninja Slushi machine for $240 and stay cool all summer

The large capacity is great for families or when friends come over. Ninja mentions this model has room to cook two racks of ribs, six steaks, a nine-pound brisket, or 30 hot dogs at once. The nonstick grill grate is perfect for getting those quintessential grill lines.

Since it's designed with premium materials, the Ninja Woodfire is weather-resistant, so there's no harm in leaving it outside for the summer. Since it's significantly smaller than a normal barbecue, this is a great option if your outdoor space is limited to a balcony or a patio. It's also an awesome appliance to pack along on the next RV or camping trip, so long as you'll have electricity.

To get that desirable smoked flavor, the Ninja Woodfire Grill & Smoker uses Ninja Woodfire Pellets, but since it's not the fuel source, you'll only need to use half a cup per smoke. This deal includes two bags of Ninja Woodfire Pellets, with each bag containing enough pellets for up to three cooking sessions.

If you love cooking outdoors but don't love using a full-size barbecue, consider the convenience and versatility of the Ninja Woodfire Grill & Smoker. This model typically costs $369.99, but it's down to just $199.99 today through the Best Buy app. Just let us know what time the barbecue starts, and we'll be right over.

SAVE $200: As of March 5, the Breville Barista Express espresso machine is $549.95 at Amazon. That's a 27% discount and a $200 price cut.

Opens in a new window Credit: Breville Breville Barista Express Espresso Machine $549.95 at Amazon
$749.95 Save $200 Get Deal

Sure, going to your favorite café every morning has major main character energy (even better if you can walk there), but romanticizing your life aside, the costs can really add up.

If you’re an espresso lover looking to save some cash and have more control over what goes into your daily cup of joe, you can get the Breville Barista Express espresso machine for just $549.95 at Amazon right now. That’s 27% off the list price and a $200 discount.

SEE ALSO: Need a robot vacuum that actually works on carpet? These 3 performed the best in my home.

The Breville Barista Express is a high-quality, semi-automatic espresso machine that can go from beans to espresso in under a minute. A built-in, conical burr grinder and simple controls make the entire espresso-making process easy. It also comes with a razor dose trimming tool, a stainless steel portafilter, one- and two-cup single-wall filter baskets, a coffee scoop, an integrated tamper, a stainless steel milk jug, a cleaning disc, and cleaning tablets.

Your perfect coffee at home is within reach.