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The U.S. government on Tuesday filed its first criminal charges against a major drug distributor and company executives over their alleged roles in fueling the nation's opioid epidemic by putting profits ahead of patients' safety.

Nothing will prepare you for Avengers: Endgame. 

The culmination of over 10 years of MCU movies will release in a matter of days but until then, spoiler-free reviews of it are finally in. 

Mashable's own Angie Han has dubbed it Marvel's biggest flex, and understandably so. It manages to wrap up with an immensely satisfying end.

SEE ALSO: 'Avengers: Endgame': Status of every character after 'Infinity War'

For more spoiler-free goodness on what to expect, read on: 

Keep those tissues handy

A.O. Scott, The New York Times

Brian Tuitt, USA Today Read more...

The payoff for long-time fans is worthwhile indeedMore about Entertainment, Marvel, Avengers, Movie Review, and Avengers Endgame

U.S. President Donald Trump met with Twitter Inc's Chief Executive Jack Dorsey on Tuesday and spent a significant time questioning him about why he has lost some Twitter followers, a person briefed on the matter said.

The U.S. Centers for Medicare and Medicaid Services will slightly increase coverage for expensive CAR-T cell therapies administered at certain large hospitals, and is considering other ways to pay more for the cancer treatments, the agency said on Tuesday.

EBay Inc raised its full-year sales and profit forecasts on Tuesday, as user-friendly changes to its ecommerce platforms attracted more customers and also increased its advertising revenue.

Snap Inc's original shows and rebuilt Android app helped it add Snapchat users for the first time in three quarters and top analyst revenue forecasts, but that was not enough to push its shares much higher after a sharp run-up this year.

Drugstore retailers Walgreens Boots Alliance Inc and Rite Aid Corp will no longer sell tobacco products to customers who are below 21 years old, amid a crackdown on widespread teenage tobacco use.

The top Democrats and Republicans on the U.S. House Energy and Commerce Committee on Tuesday wrote Google Chief Executive Sundar Pichai raising concerns about reports of a massive database known as Sensorvault containing precise consumer location information on hundreds of millions of devices.

The subtweet is coming from inside the house.

Twitter co-founder and CEO Jack Dorsey was on the receiving end of a not-so-subtle own today following an April 23 Oval Office meeting with Donald Trump. It seems that Biz Stone, one of the company's original co-founders, doesn't think too highly of the CEO's justification for meeting with the President. And so, Stone did what many frustrated Twitter users do: he used the platform to make his displeasure known. 

SEE ALSO: Twitter users trolled Jack Dorsey on a giant projection screen during his TED Talk

"I’ve got a meeting today that could result in division," wrote Stone. "I’m letting you know so you don’t hear it from someone else first. I’m volunteering at a grade school math center. I’m hoping both parties will learn from the exchange." Read more...

More about Twitter, Jack Dorsey, Donald Trump, Biz Stone, and Tech

Chipmaker Texas Instruments said on Tuesday a slowdown in demand for microchips that started late last year may last a few more quarters. The warning from the company, often seen as a bellwether for a semiconductor industry, dragged its shares 3 percent lower to $113.88.

Britain will allow China's Huawei Technologies limited access to the next generation of mobile network, known as 5G, the Daily Telegraph reported on Tuesday, without citing sources.

The following is a SPOILER-FREE review of Avengers: Endgame.

Avengers: Endgame is not the best Marvel movie ever made. It's not the prettiest or the funniest; it won't blow your mind with new ideas or complicated character development.

But it is the most Marvel movie ever made, and there's something incredible about that.

This is Marvel flexing, building on over 10 years and 20-plus films of careful groundwork and intricate planning to show us what it can do that no other movie franchise can. As such, it's an immensely satisfying finish to this era of the series. 

Its magic does require some prior buy-in. This is a film designed for fans, stuffed as it is with callbacks, cameos, and Easter eggs. Certain arcs come full circle after years and years; others are revisited and refashioned into something different. Newcomers will likely find themselves totally lost in this tangle of characters and relationships and mythologies.  Read more...

More about Movies, Avengers Endgame, Entertainment, Comic Culture, and Movies Tv Shows

A total of 156 people in 10 states have been infected with E. coli after eating tainted ground beef at home and in restaurants since the beginning of March, the U.S. Centers for Disease Control and Prevention (CDC) said on Tuesday.

U.S. President Donald Trump met with Twitter Inc's Chief Executive Jack Dorsey on Tuesday, hours after attacking the social media company over his claims it is biased against conservatives.

Last year Ford brought on the startup Autonomic to create the Transportation Mobility Cloud, or TMC, to build "smart" car applications for real-time data and connectivity in cars. On Tuesday, Ford announced Amazon Web Services will power the cloud-based platform.

The platform has since been available for all car makers, not just Ford. It creates a space for services and apps, like those used for parking, real-time traffic information, and in-car payment options. Think of it like the Apple App Store, but with apps and services made solely for the car.

SEE ALSO: Adobe’s first auto app will give real-time car maintenance tips Read more...

More about Ford, Android Auto, Carplay, Connected Car, and Infotainment

The top Democrats and Republicans on the U.S. House Energy and Commerce Committee on Tuesday wrote Google Chief Executive Sundar Pichai raising concerns about reports of a massive database of precise consumer location information on hundreds of millions of consumers known as "Sensorvault."

(Reuters Health) - One in five U.S. children and young adults don't drink any water at all on a typical day, and a new study suggests they consume almost twice as many calories from sodas and sugary drinks as young people who do drink water.

(Reuters Health) - Cancer patients and survivors are often at high risk of heart disease, so heart and cancer doctors should consider providing cardio-oncology rehabilitation as patients move through their cancer treatment, the American Heart Association (AHA) urges in a new scientific statement.

A lot of viewers are feeling an exaggerated smiley-squint from Daenerys during her heart-to-heart  stand-off with Sansa in the most recent Game of Thrones episode. 

Caption thispic.twitter.com/g85egCy4Nc

— doom (@reallyhalalfood) April 22, 2019

The Daenerys-Sansa exchange didn't get the same notice as, say, Brienne's knighthood or Daenerys' other big Stark one-on-one conversation, but it's pivotal all the same as it sets up a potential ongoing feud between the Mother of Dragons and, maybe, the Queen of the North. 

Provided they survive the upcoming Battle of Winterfell, of course.

In the meantime, though, the moment got meme'd as Twitter user @reallyhalalfood called for a caption contest of the moment and, yes, Twitter delivered.  Read more...

More about Memes, Game Of Thrones, Sansa Stark, Daenerys Targaryen, and Culture