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Amazon Prime Day is here: We found the 75+ best live deals on Apple, Sony, Kindle, and Lego favorites

Mashable - 3 hours 54 min ago
The best Amazon Prime Day deals: Best Apple deal Apple Watch Series 11 (GPS, 42mm) $279 at Amazon (save $120) Get Deal Best headphones deal Sony WH-1000XM5 Noise-Cancelling Headphones $198 at Amazon (save $201.99) Get Deal Best Kindle Deal Amazon Kindle Paperwhite $124.99 at Amazon (save $35) Get Deal Best Echo Deal Amazon Echo Spot $44.99 at Amazon (save $35) Get Deal Best kitchen deal Instant Pot 6-quart Vortex Plus Air Fryer $69.99 at Amazon (save $60.04) Get Deal Best floor care deal Bissell Little Green Mini $79.99 at Amazon (save $20) Get Deal Best DJI deal DJI Mini 3 $269 at Amazon (save $150) Get Deal Best speaker deal Bose Soundlink Flex Bluetooth Speaker $99 at Amazon (save $50) Get Deal Best TV deal Samsung 65-inch S90F OLED 4K Smart TV $1,197.99 at Amazon (save $500) Get Deal Best Lego deal Lego Star Wars Imperial Star Destroyer Set $111.99 at Amazon (save $48) Get Deal

Prime Day 2026 rolls on. After weeks of early deals and so much anticipation, Amazon's flagship summer sale is now in its second day. If you're a Prime member, this is your opportunity to save on almost anything, from boring household essentials like dish soap to big-ticket splurges like a new 65-inch OLED TV. If you're not sure where to start, we've gathered all of the best Prime Day deals, including unprecedented price drops on the entire Apple Watch lineup, Sony headphones, and Kindle e-readers. There's a deal for pretty much everyone.

Prime Day usually takes place in July, but this year, Amazon decided to shake things up and run the sale in June. So, if you haven't already heard the news, Amazon Prime Day 2026 runs until Friday, June 26. The timing may have changed, but we're still seeing the same great seasonal savings on products from Apple, DJI, Dyson, Lego, Pokémon, and Samsung.

SEE ALSO: The top 30+ Prime Day tech deals, hand-picked by a tech editor on a budget

Mashable shopping experts are closely monitoring the latest discounts and collecting all of the top Prime Day deals into this one-stop shopping guide, so keep checking back for new deals. We're also tracking prices at the best anti-Prime Day sales from Best Buy, Target, Walmart, and beyond, so we'll be sure to point you towards the lowest possible price.

Deals marked with a ✅ are Mashable editor favorites. Deals marked with a strikethrough are no longer available.

Best Prime Day Apple deal Opens in a new window Credit: Apple Apple Watch Series 11 (GPS, 42mm) ✅ $279 at Amazon
$399 Save $120   Get Deal

We're obviously hunting for the best Apple deals during Prime Day, and right now, the entire Apple Watch lineup is at record-low prices. That means you can save over $100 on the Apple Watch Series 11, a Mashable Choice product. In his review, Mashable's Stan Schroeder said, "the Apple Watch Series 11 isn't all that different from last year's model, but it has a significantly longer battery life, and that's a huge deal."

AirPods dealsiPad dealsMacBook dealsBest Prime Day headphones deal Opens in a new window Credit: Sony Sony WH-1000XM5 Noise-Cancelling Headphones ✅ $198 at Amazon
$399.99 Save $201.99   Get Deal

The best deal on headphones goes to the Sony WH-1000XM5s, an older pair of flagship cans that we still love and recommend. "They [have] unbeatable ANC and sound for the money, and even in 2026, they sound shockingly good," writes Bethany Allard, our resident headphones expert. Normally $399.99, they're marked down to just $198 for Prime Day — a 50% savings and their lowest price ever.

More headphones dealsMore earbuds dealsBest Prime Day Amazon device deals Opens in a new window Credit: Amazon Amazon Echo Spot $44.99 at Amazon
$79.99 Save $35.00   Get Deal

Amazon's latest Echo devices, the Echo Dot Max and Echo Studio, have both hit new, all-time low prices this Prime Day. But the biggest discount is going to the Echo Spot, its smart alarm clock. This tiny speaker sits compactly on nightstands but provides everything you need to start your morning, including a weather report and tunes to get you out of bed.

You can now get the Amazon Echo Spot for just $44.99. That saves you $35 off its $79.99 price tag for a 44% discount.

More Echo dealsMore Amazon device dealsBest Prime Day Kindle deals Opens in a new window Credit: Amazon Amazon Kindle Paperwhite ✅ $124.99 at Amazon
$159.99 Save $35.00   Get Deal

Our resident e-reader expert, Samantha Mangino, counts the Kindle Paperwhite Signature Edition as her daily driver, but for most shoppers, we have to recommend the excellent Kindle Paperwhite, which has proven to be one of the most popular Prime Day deals among Mashable readers this year. Compared to the regular Kindle, the Paperwhite has a larger display, better battery life, a waterproof rating, and an adjustable warm light.

More Kindle dealsBest Prime Day laptop deal Opens in a new window Credit: Microsoft Microsoft Surface Laptop 7, 15-inch (Snapdragon X Elite, 16GB RAM, 1TB SSD) ✅ $1,229.99 at Amazon
$2,099.99 Save $870.00   Get Deal

Read Mashable's full review of the Microsoft Surface Laptop 7.

Senior Shopping Reporter Haley Henschel says, "We loved the Surface Laptop 7 back when it launched in 2024. While its CPU isn't the freshest anymore, it still impresses as a whole: It features a 23-hour battery life, a microSDXC card slot, and a 2.5K touchscreen that's brighter and smoother than a 15-inch MacBook Air's screen.

Amazon's amazing Prime Day deal on this 15-inch model comes just a week after Microsoft announced the very similar Surface Laptop 8 (which isn't on sale just yet). It's currently listed for just $1,229.99 — a whopping 44% off its regular retail price of $2,099.99. I wouldn't be surprised if it disappears long before Prime Day ends, considering the exact same model sold out at Best Buy after dropping to $1,699.99 there."

More Prime Day laptop deals

For discounts on MacBooks, scroll back up to the Apple section in this story or check out our dedicated Prime Day MacBook deals guide.

Best Prime Day DJI deal Opens in a new window Credit: DJI DJI Mini 3 $269 at Amazon
$419 Save $150   Get Deal

DJI's entire fleet of gadgets is on sale this Prime Day, and this deal on its DJI Mini 3 is a standout. Amazon has it discounted to $269, or 36% off — its lowest price ever. (It was $30 more expensive during Amazon's Big Spring Sale in March.) This lightweight entry-level drone can shoot 4K video and fly for almost 40 minutes on a single charge.

More DJI drone dealsDJI camera dealsDJI creator tools on saleBest Prime Day home and kitchen deal Opens in a new window Credit: InstantPot Instant Pot 6-quart Vortex Plus Air Fryer $69.99 at Amazon
$149.99 Save $80.00   Get Deal

Instant Pot and air fryer deals are staples of Prime Day, and this deal combines them both into one offer. Save over 50% on this Instant Pot air fryer, with a spacious inner basket and simple controls. It's currently the No. 1 selling air fryer on Amazon for Prime Day.

More kitchen dealsHome dealsBest Prime Day speaker deal Opens in a new window Credit: Sony Sony PS-LX3BT Wireless Bluetooth Turntable $248 at Amazon
$398 Save $150   Get Deal

OK, you got us, this isn't technically a speaker. (If you're looking for Bluetooth speakers, check out our Prime Day speaker deals guide.) But we had to find a place to highlight this stellar deal on the newly released Sony PS-LX3BT Wireless Bluetooth Turntable.

Mashable's Haley Heschel loved this wireless record player, writing in her review that the "PS-LX3BT is stupidly simple to use." If you're not ready to invest in HiFi equipment that will cost you thousands of dollars, this is a great beginner-friendly turntable for vinyl lovers.

More speaker dealsBest Prime Day power station deals Opens in a new window Credit: Bluetti Anker Solix C2000 Gen 2 Portable Power Station $199 at Amazon
$299 Save $100   Get Deal

Ready for summer adventures? If you're gearing up to pack the car and head into nature, don't forget to invest in a portable power station to keep your campsite powered. Plus, it can serve as an at-home power backup in an emergency.

Prime Day and Black Friday are the best times of year to buy these popular devices, and you can often find savings of 50% or more on Mashable-tested brands like Anker, Jackery, and Bluetti. If you're looking to buy your first-ever power station, an affordable new model from Bluetti is on sale.

More portable power station dealsBest Prime Day TV deals Opens in a new window Credit: Samsung Samsung 65-inch S90F OLED 4K TV $1,197.99 at Amazon
$1,697.99 Save $500   Get Deal

Enjoying the World Cup? If you want to watch every heart-racing moment in 4K and your TV isn't up to par, then look for Prime Day deals on award-winning OLED and Micro RGB TVs. Case in point: the Samsung 65-inch S90F OLED 4K Smart TV, on sale now. Normally $1,697.99, it's down to $1,197.99, saving you $500. That's a new all-time low price.

More TV dealsBest Prime Day vacuum deal Opens in a new window Credit: Eufy Eufy C28 Robot Vacuum and Mop $449.99 at Amazon
$799.99 Save $350   Get Deal

Mashable's resident vacuum guru, Leah Stodart, named the Eufy C28 Robot Vacuum and Mop the best affordable vacuum-and-mop combo. Despite its budget price, Stodart says it's the most heavy-duty robot mop you'll find, delivering spotless cleans. Get the Eufy C28 for just $449.99 during Prime Day. That's the vacuum's lowest price ever, offering $350 in savings.

More robot vacuum dealsMore vacuum dealsUpholstery cleaner dealsBest Prime Day Lego deal Opens in a new window Credit: Lego Lego Star Wars Imperial Star Destroyer Set $111.99 at Amazon
$159.99 Save $48.00   Get Deal

Lately, we've been loving Star Wars Lego sets, and this epic Star Destroyer kit is down to its best-ever price at Amazon. If you're a Prime member and a Star Wars fan, you can pick up this 1,555-piece set for $119, a 30% discount. And if you're looking for more Lego sets, check out our complete guide to the best Prime Day Lego deals.

More Lego dealsBest Prime Day camping and outdoor deal Opens in a new window Credit: Yeti Yeti Hopper M Series Portable Soft Coolers ✅ $227.50 at Amazon
$350 Save $122.50 Lighting deal Get Deal

Amazon just dropped a bunch of new Prime Day camping deals, part of its daily deal drops. The standout is definitely this portable soft cooler from Yeti, which our tech editor Timothy Werth has tested on multiple beach days, even though it's not actually a tech product. Hey, sometimes you need to unplug. Yeti's coolers are famous for their durability, and they rarely go on sale outside of Prime Day and Black Friday.

More outdoor and camping dealsBest Prime Day fitness tracker deal Opens in a new window Credit: Oura Oura Ring 4 ✅ $259 at Amazon
$499 Save $240 Rings start at $214.70, depending on the finish Get Deal

Multiple Mashable team members have tested (and loved) the Oura Ring 4. While it's recently been replaced by the slightly thinner Oura Ring 5, we're big fans of this smart ring. One of our reporters even wore this ring while training for and then running the New York City marathon. While prices vary based on the ring size, the Oura Ring 4 is starting at just $214 for Prime Day, a price we've never seen before and a big discount from the $349 list price.

More fitness tracker deals

Note: For Apple Watch deals, scroll back to the Apple section of this story.

Best Prime Day streaming deal Opens in a new window Credit: HBO HBO Max save 40% on annual subscriptions Get Deal

If you've been feeling left out of the House of the Dragon or Hacks hype, this is easily the best week of the year to sign up for HBO Max — it even beats Black Friday, in terms of how many tiers get the discount. The HBO Max Prime Day deal makes annual subscriptions 40% cheaper than usual. Pay $78.99 for a year of the Basic With Ads tier, $132.99 for a year of the Standard tier, or $164.99 for a year of the Premium tier.

More streaming dealsBest Prime Day trading card deal Opens in a new window Credit: Pokémon Pokémon TCG Mega Evolution Chaos Rising Booster Bundle $45.88 at Amazon
$59.99 Save $14.11   Get Deal

Pokémon is celebrating its monumental 30th anniversary in 2026, and the card game and franchise remain as popular as ever. Currently, this is the best-selling Pokémon card bundle at Amazon, and it's also proven to be a hit with Mashable readers, in particular. We've also got a full selection of Pokémon deals.

More Prime Day deals on trading cards

Best Prime Day gaming deal

Opens in a new window Credit: Samsung Samsung G8 OLED 4K Gaming Monitor, 32 inches ✅ $657.77 at Amazon
$1,249.99 Save $592.22 New release Get Deal

Mashable's tech editor has reviewed Samsung OLED gaming monitors, and he previewed the new G8 model ahead of its release last month. Despite hitting the market less than 30 days ago, Samsung and Amazon are offering a steep 47% discount on this device. So, as much as it pains us to recommend a $650 product as the best Prime Day gaming deal, nothing else really comes close.

With a sleek metal stand, a beautiful 4K display, and Samsung's latest gaming display technology, this is a monitor for serious gamers. Grab it while it's available with a serious discount.

More Prime Day gaming dealsBest Prime Day book deal Opens in a new window Credit: Poisoned Pen Press "Dear Debbie" by Freida McFadden $12.74 at Amazon
$32.99 Save $20.25   Get Deal

Named one of Goodreads most popular books of 2026 (so far), Freida McFadden's Dear Debbie follows advice columnist Debbie Mullen, who takes a rather extreme approach to fixing her own life as it starts to crumble. Down to just $12.74, this is one of the cheapest hardcover books you can pick up this Prime Day.

More Prime Day book deals

Still haven't found what you're looking for? Check out our Prime Day 2026 live blog, where we're providing real-time updates on the latest deals, inventory changes, and competitor sales.

Categories: IT General, Technology

Prime Day 2026: Get live updates on Amazon deals from Apple, Bose, Lego, and Sony

Mashable - 3 hours 55 min ago

Amazon's annual Prime Day sale runs from June 23 to 26 this year. That's right, Amazon has shifted the event from mid-July to late June.

Without a doubt, Prime Day 2026 will be one of the biggest sales events on the shopping calendar, second only to Black Friday. This huge event will go hard on just about every category: You can expect significant savings on Apple gadgets, limited-time price cuts on Bose headphones, and all-time lows on Samsung OLED TVs and gaming monitors. Our professional deal hunters are ready and waiting to help you save, and we'll be cross-checking prices at Amazon, Best Buy, Target, and Walmart to make sure you get the lowest prices.

We've lined up all the best deals from Prime Day. Keep scrolling for the full schedule of events and the latest live updates, price drops, low-stock alerts, and news from the Amazon sale.

Categories: IT General, Technology

The best Prime Day streaming deals right now: 10+ subscriptions for less than $1

Mashable - 3 hours 59 min ago
The best Prime Day streaming deals at a glance: Best long-term deal HBO Max Standard annual subscription $132.99 (save $52) Get Deal Best add-on deal Paramount+ Premium $0.99/month for 2 months (save $26) Get Deal Best music streaming deal Amazon Music Unlimited free for 4 months (save $47.96) Get Deal Best premium Prime Video add-on deal Apple TV $5.99/month for 2 months (save $14) Get Deal Best audiobook streaming deal Audible Standard free for 3 months (save $26.97) Get Deal Best slept-on streaming deal AMC+ Premium (Prime Video add-on) $0.99/month for 2 months (save $20) Get Deal

Last year, Amazon surprised us by dropping a boatload of Prime Day streaming deals for the first time. In 2026, it's basically rinse and repeat. And that's not a bad thing.

Prime Day isn't just for deals on TVs and headphones anymore — it's also a great time to load up your digital libraries with streaming subscriptions, so long as you're a Prime member. (Not yet a member? Sign up here.) One of the biggest perks of having a Prime account is gaining access to Prime Video, Amazon's own streaming service. While Prime Video itself isn't on sale, tons of subscription add-ons are, including premium options like Apple TV, AMC+, and Paramount+.

In the days leading up to the official Prime Day kickoff (which takes place June 23 through 26 this year), HBO Max also dropped a killer deal. It quickly took our top spot for the best Prime Day streaming deal.

I'll be keeping an eye out for you, and updating this list if any new streaming deals roll in. I'm not expecting much to change throughout Prime Day, so be sure to jump on these deals ASAP. This will likely be your only chance to snag a steep discount until the end of the year — so, act fast if you see a deal you like.

Best Prime Day long-term streaming deal Opens in a new window Credit: HBO Max HBO Max 40% off annual subscriptions Get Deal Opens in a new window Credit: HBO Max HBO Max (Prime Video add-on) 40% off annual subscriptions Get Deal Why we like it

HBO Max always gives us one of the best streaming deals for Black Friday, but this is the first time it's decided to hop aboard the Prime Day express. And it's kicking off its Prime Day deal debut with a bang: new and returning subscribers can get any annual subscription for 40% off. Yes, that means this deal isn't just limited to the ad-supported tier like it is on Black Friday.

Typically, HBO Max annual subscriptions cost $109.99 for the Basic with ads tier, $184.99 for Standard (no ads), and $229.99 for Premium (no ads + 4K). Through July 15, however, you'll only pay $78.99, $132.99, or $164.99, respectively. After your first year, your subscription will revert to full price unless you cancel. Still, that's 12 whole months of streaming for 40% less than usual.

Psst: If you don't want to deal with logging into another streaming service, this deal is also available in the form of a Prime Video add-on.

Best Prime Day streaming add-on deal Paramount+ streaming deals: Standalone deal Paramount+ Premium $0.99/month for 2 months (save $13/month) Get Deal prime video add-on Paramount+ (Prime Video add-on) $0.99/month for 2 months (save $13/month) Get Deal Roku add-on Paramount+ Premium (Roku add-on) $0.99/month for 2 months (save $13/month) Get Deal Why we like it

Like clockwork, we can always count on Paramount+ to dish out one of the best streaming deals during major shopping events. The streamer has resurrected the exact same streaming deal from last Prime Day for 2026, only this time it's technically a better offer since Paramount+ raised its prices earlier this year. Typically $13.99 per month for a Premium subscription (that's the ad-free tier with Showtime), you'll get two months for just 99 cents a piece. That saves you $26 total.

The Paramount+ library is surprisingly robust. Premium subscribers can enjoy Paramount+ Originals like Landman and RuPaul Drag Race All Stars, Showtime series like Dexter Resurrection and Yellowjackets, CBS shows like Survivor and Big Brother live, UFC fights, and nostalgic shows from Nickelodeon and MTV. That's not even counting the massive movie lineup (including Paramount Pictures movies straight from the theater).

The discount is only valid through the end of Prime Day on June 26, so be sure to sign up before then. You can grab the deal directly through Paramount+ itself or as a subscription add-on via Prime Video or Roku.

Best Prime Day music streaming deal Opens in a new window Credit: Amazon Music Unlimited Amazon Music Unlimited free for 4 months (save $11.99/month) Get Deal Why we like it

If you're not committed to a music streamer, now's a good time to check out Amazon Music Unlimited without spending a cent. Through June 29, new subscribers can secure four free months. Typically $11.99 per month for Prime members, that's a total of $47.96 in savings. Amazon Music Unlimited unlocks a massive music catalog that you can listen to on-demand, ad-free, and in the highest quality possible. Beyond music itself, Unlimited subscriptions also include "the most ad-free podcasts" of any of the major music apps, as well as one free audiobook per month via Audible. Even if you do already subscribe to another music streaming service, it's worth it to take a pause from payments for four months and lock in this deal.

More Prime Day streaming dealsPrime Day streaming stick deals
Categories: IT General, Technology

We found 10+ Prime Day deals on MicroSD and portable SSDs for a brief respite from RAMageddon

Mashable - 4 hours 12 min ago
Best Prime Day MicroSD and portable SSD deals Best MicroSD Card deal Samsung T7 MicroSDXC, 1TB $239.99 (Save $80) Get Deal Best portable SSD deal Sandisk Portable SSD, 1TB $135.99 (Save $24) Get Deal Best for Switch 2 Samsung P9 Express MicroSD, 256GB $39.99 (Save $40) Get Deal

Thanks to the global memory crisis known as RAMageddon, prices on memory products like hard drives, MicroSD cards, and portable SSDs have gone up, up, and up. Experts interviewed by Mashable say the memory crisis will get worse before it gets better, so this is a rare opportunity to find deals on these products.

MicroSD and portable SSDs are a staple of Prime Day and more relevant than ever in light of RAMageddon. We found the best deals in the memory category, so now is the time to take advantage of these microSD and portable SSD offers, with Prime Day deals from Lexar, Samsung, and SanDisk.

SEE ALSO: Prime Day 2026: Get live updates on Amazon deals from Apple, Bose, Lego, and Sony

So, if your Nintendo Switch 2 or hard drive has been dangerously full, now's the best time to restock.

Best MicroSD Card deal Opens in a new window Credit: Samsung Samsung T7 MicroSDXC 1TB $239.99 at Amazon
$319.99 Save $80   Get Deal

If you're maxing out device storage, enough is enough. The Samsung T7 brings an immense amount of storage space (1TB to be exact) in a tiny package. It can store your favorite games and capture high-res photos and 4K video in real time. It pulls a lot of weight and right now, you can pay just $239.99 for the MicroSD card, saving you $80 during Prime Day. For some slightly cheaper microSDs, check out Lexar's SD cards during Prime Day.

Best portable SSD deal Opens in a new window Credit: Sandisk Sandisk Portable SSD, 1TB $135.99
$159.99 Save $24   Get Deal

A portable SSD provides an immense amount of storage in a portable package. This Sandisk portable SSD is made for people on the go with a loop on it for easy attachment to a backpack or belt loop. With 1TB of storage, Sandisk claims excellent performance with up to 800MB/s speeds. Get it for just $135.99 and save $24 during Prime Day.

Best deal for Switch 2 Opens in a new window Credit: Samsung Samsung P9 Express MicroSD, 256GB $39.99 at Amazon
$79.99 Save $40.00   Get Deal

If you're in the market for a microSD card for your Nintendo Switch 2, you can grab the Samsung P9 Express MicroSD for 50% off during Prime Day. It has transfer speeds up to 800MB/s and 256GB of storage, so you can store games on it in a safe spot.

More MicroSD and Portable SSD deals

MicroSDs

Portable SSDs

Categories: IT General, Technology

GTA VI price revealed: What you get for the $99 ultimate edition

Mashable - 4 hours 14 min ago

If you were looking to lock down a Grand Theft Auto VI pre-order this week, Rockstar Games just released some very important information about that.

Specifically, Rockstar finally gave us a price for the game. There is a standard edition for $79.99, making GTA VI the first game since Mario Kart World to start at that price. That's not terribly surprising, nor is the fact that Rockstar is also charging $99.99 for an Ultimate Edition of the game.

SEE ALSO: Amazon Prime Day is here: We found 75+ deals on Apple, Sony, Kindle, and Lego favorites

What exactly does that price get you? According to Rockstar, it's an "exclusive collection of premium vehicles, weapons, apparel, and action around every corner." The official website for the game has some more specific information on that front. The Ultimate Edition of GTA VI includes:

  • Several exclusive vehicles

  • Exclusive weapons

  • A bevy of shops for fashion, vehicle mods, and tattoos that only exist in the Ultimate Edition

Locking outfits and even vehicles behind an Ultimate Edition purchase is pretty normal stuff for a game like this, but putting several shops in the game that can only be accessed by players who bought the more expensive version is...innovative, though maybe not in the way people want GTA VI to be.

It should also be noted that Rockstar emphasized in its news drop on Wednesday that GTA VI is, for now, a single-player experience. Barring the unexpected, there will not be an online portion of the game available at launch. That was also true of GTA V and Red Dead Redemption 2. Both of those games got multiplayer modes later, with V's being a cornerstone of Rockstar's financial success for the last decade.

Categories: IT General, Technology

I test e-readers, and Ive found the best-ever Kindle deals to shop on Prime Day

Mashable - 4 hours 16 min ago
The best Prime Day Kindle deals: Best Kindle Deal Amazon Kindle Paperwhite Signature Edition $144.99 (Save $55) Get Deal Best Colorsoft Deal Amazon Kindle Colorsoft $159.99 (Save $90) Get Deal Best Scribe Deal Amazon Kindle Scribe (32GB) $379.99 (Save $120) Get Deal Best Kids Kindle Deal Kindle Colorsoft Kids $179.99 (Save $90) Get Deal

Testing Kindles and e-readers is my job, but it's also my passion. I use my Kindle Paperwhite every day — unless I'm testing a new e-reader — and it's accompanied me on many a summer adventure. So, while I spend a lot of time convincing Mashable readers to buy my favorite e-readers, I also track the best times to buy one.

Amazon Prime Day 2026 is now in full swing, and Kindle deals are back in a big way. Several models have dropped to record-low prices, and the newer Kindle Scribes are finally seeing discounts, too.

SEE ALSO: Everything you need to know about Amazon Prime Day 2026

So TL;DR, if you're eyeing a Kindle, now is the time to buy. Here are the very best Kindle deals to shop during Prime Day.

Best Prime Day Kindle deal Opens in a new window Credit: Amazon Amazon Kindle Paperwhite Signature Edition $144.99 at Amazon
$199.99 Save $55   Get Deal Why we like it

My absolute favorite Prime Day Kindle deal is on the Amazon Kindle Paperwhite Signature Edition. It's the e-reader that I use everyday, and it just hit a new all-time low price of $144.99. That makes it cheaper than the Paperwhite at full-price, but it also makes it the same price as the currently on sale Paperwhite without ads.

However, the Signature Edition is far more bang for your buck as it comes with twice the storage, an auto-adjusting front light, and wireless charging. It's an exceptional deal and the device's new lowest-price ever.

Interested in a different Kindle model? Explore all the Kindles on sale during Prime Day.

More Prime Day Kindle deals

Kids Kindles

How do Kindle prices compare to previous sales?

Having tracked prices on Kindles for years, I have a pretty good sense of how much Amazon's e-readers cost during a sale. So how are Kindle deals this Prime Day?

We tracked the prices on the Kindle and Kindle Paperwhite over the past four sales to predict this years prices. Credit: Mashable

The Kindle Paperwhite's lowest price ever is $124.99, which the device dropped to during Black Friday, Prime Big Deals Days, and of course, last year's Prime Day. This year it's back down to $124.99. The Signature Edition on the other hand reached a new low of $144.99, just $20 more for a boatload of extra features.

The deal I'm most disappointed in is on the basic Kindle, which previously dropped to $79.99. This Prime Day, it's $5 more for $84.99. New deals this Prime Day include the latest Kindle Scribe and Scribe Colorsoft, both getting their first price drops since being released.

Categories: IT General, Technology

The Steam Machine is a computer for no one

How-To Geek - 4 hours 19 min ago

The Steam Machine has been revealed in its final retail form, and we know what the price is. At a starting price of $1,049, it's much more expensive than the PlayStation 5 Pro, yet the base model is less capacious than a standard PlayStation 5. The PS5 also comes with a controller, whereas with the Steam Machine you still need to add the price of a controller to your budget.

Categories: IT General, Technology

When does Prime Day end? Heres how long the sale lasts in 2026.

Mashable - 4 hours 21 min ago

Prime Day 2026 has started out with a bang, offering the deep discounts we've come to expect over the years.

But it won't last forever! And people seem to be aware of this fact, as we've seen a spike in people asking exactly when Amazon Prime Day will end this year. No one wants to deal with FOMO when it comes to saving hundreds of dollars on the best Prime Day deals.

So, mark your calendar: Prime Day 2026 ends on Friday, June 26.

SEE ALSO: Prime Day 2026: Get live updates on Amazon deals from Apple, Bose, Lego, and Sony How long is Prime Day 2026? When exactly does it end?

Amazon Prime Day 2026 started at 3:01 a.m. ET on Tuesday, June 23. The Amazon sale will come to an end at exactly 2:59 p.m. ET on Friday, June 26, 2026 (or 11:59 p.m. PT). At that point, you can expect most deals on major brands like Apple, Lego, and Amazon's own devices will have ended. As of this writing, we're on day two of the four-day mega sale.

Some price drops do tend to linger once the sale is technically over, so it's worth checking to see if the products you've had your eye on are still available on sale. It's a bit of a gamble at that point, though, so we recommend grabbing deals sooner rather than later.

Best things to buy on Prime Day

Like Black Friday, Prime Day only comes around once a year — though there are other sales to be had year-round from Amazon. So it's definitely a bummer to think you may have missed one of the most lucrative events of the year when it comes to saving money.

SEE ALSO: The best anti-Prime Day sales 2026: Best Buy, Target, Walmart, and more

The good news is that you still have plenty of time to find a bargain. Below, find a selection of some of the best Amazon Prime Day deals Mashable has curated for our readers. And be sure to follow along in our Prime Day hub for the latest and greatest price drops during (and after) the event.

Apple deals

AirPods deals

Apple Watch deals

Ipad deals

MacBook deals

Streaming deals

Streaming services

Streaming sticks

Amazon device deals

Echo deals

Kindle deals

Fire TV deals

TV deals

65-inch TVs

75-inch TVs

85-inch TVs

Categories: IT General, Technology

Snag these Nintendo Switch deals during Prime Day 2026

Mashable - 4 hours 30 min ago
The best early Prime Day Nintendo Switch deals Best early Prime Day Nintendo Switch Deal Nintendo Switch 2: Choose Your Game Bundle $499 Get Deal Best early Prime Day Nintendo Switch game deal Star Fox $49.94 (Save $10.04) Get Deal Best early Prime Day Nintendo Switch accessory deal 8BitDo Ultimate 2 Bluetooth Controller $51.28 (Save $18.70) Get Deal

Amazon Prime Day is here once again, and there are plenty of deals on offer for anyone with a Nintendo Switch on their wishlist. Several of our favorite Switch and Switch 2 games and accessories are discounted right now, with more to come.

The four-day sale kicked off with a wide selection of goodies to claim, including a bundle with the actual console itself. The Switch 2 turns one this month and is set for a price increase to $499.99 on September 1 rather than a cut. The real savings you'll find right now are on games and accessories.

Ready to shop? We've curated the best Prime Day Nintendo Switch deals here for you to add to your cart right now. We'll keep this guide updated as the sale goes on, so keep checking back to find the best Switch and Switch 2 discounts like the ones below.

Best Prime Day Nintendo Switch deal Opens in a new window Credit: Amazon Nintendo Switch 2: Choose Your Game Bundle $499 at Amazon
  Get Deal Why we like it

While technically not a "deal" in the sense that you'll save money for Prime Day, this bundle is a good way to pick up both a Nintendo Switch 2 and the game of your choice out of a decent selection. You get the console itself, Joy-Con controllers, and games like Pokémon Pokopia, Mario Kart World, and Donkey Kong Bananza with the bundle, so you can get started playing right away. With a 7.9-inch LCD touch screen, three play modes, and backwards compatibility with most Nintendo Switch titles, it's well worth picking up, especially given the price hike coming in September.

Best Prime Day Nintendo Switch game deal Opens in a new window Credit: Amazon Star Fox $49.94 at Amazon
$59.99 Save $10.05   Get Deal Why we like it

This remake of the Nintendo classic is out this week, and you can go ahead and save on it before its release. Fly through space on a fast and furious adventure with Fox, Slippy, Peppy, and Falco as you experience this new take on the Star Fox 64 story. It has new fully-voiced dialogue, a new orchestral soundtrack, and completely new graphics for a whole new generation. You can also invite a second player to join you on your adventures.

Best Prime Day Nintendo Switch accessory deal Opens in a new window Credit: Amazon 8BitDo Ultimate 2 Bluetooth Controller $51.28 at Amazon
$69.99 Save $18.71   Get Deal Why we like it

This excellent Pro Controller alternative is much cheaper at the moment, and it'll get the job done with style and panache. It has special joysticks with better precision, higher sensitivity, and improved durability so no matter what game you're into, you know it'll feel great to play. It also features an integrated charging dock so you can always stay charged up, no matter what kind of schedule you keep. Plus, it has a slew of customizable features you can change up for different games, offering a much more bombastic experience than a Joy-Con controller.

More Nintendo Switch deals
Categories: IT General, Technology

How I turned a Raspberry Pi into an automatic podcast downloading server

How-To Geek - 4 hours 34 min ago

I love a good podcast, but there are so many available that it can be hard to know what to listen to next. I decided to build my own podcast server using a Raspberry Pi, which would automatically download the latest episodes of my favorite podcasts.

Categories: IT General, Technology

I track TV prices all year: Here are the Prime Day TV deals that are actually worth buying

Mashable - 4 hours 48 min ago
The best Prime Day TV deals at a glance: Best 55-inch TV deal Hisense 55-inch U6 Pro Mini LED QLED 4K Fire TV $529.99 (save $320) Get Deal Best Frame TV deal Samsung 55-inch The Frame Pro Neo QLED TV $1,267.99 (Save $230 + get a free Echo Show 11) Get Deal Best 65-inch TV deal TCL 65-inch QM8L SQD Mini LED 4K TV $1,497.99 (save $1,002) Get Deal Best 75-inch TV deal Hisense 75-inch U7 Mini LED 4K TV $999.99 (save $1,000) Get Deal Best Amazon TV deal Amazon 65-inch Ember Artline 4K QLED Fire TV $799.99 (save $300 with code SAVEFTV) Get Deal

Prime Day season is one of the best times of year to buy a TV on sale. Usually in July, Prime Day is here earlier than usual, running June 23 to 26. Maybe Amazon knew that the World Cup would make everyone realize they were in need of a new TV.

Leading up to Prime Day, the TV deals were hot as we saw savings over $1,000. Now that Amazon's flagship sale is officially underway, we're seeing even bigger discounts on already great deals. Not to mention, Amazon is running a stellar bundle on Frame TVs and the Echo 8.

So let's get into all the best TV deals to shop during Prime Day. Be sure to check back throughout the sale for updates and follow along with all other categories in Mashable's Prime Day hub.

SEE ALSO: 15+ streaming services you can get for 99 cents, plus more early Prime Day streaming deals Best Prime Day TV deal Opens in a new window Credit: Hisense Hisense 75-inch U7 Mini LED 4K TV $999.99 at Amazon
$1,999.99 Save $1,000   Get Deal Why we like it

Hisense finally launched its highly-awaited RGB TVs on June 2. While both the UR8 and UR9 RGB TVs are on sale at Best Buy, there's another 2026 Hisense TV with a much wilder discount: The 75-inch Hisense U7 Mini LED TV is just $999.99 exclusively for Prime members after a massive 50% price drop from its usual $1,999.99.

Just released in March, the Hisense U7 series has a pretty incredible lighting system for its price range. Its backlight benefits from full-array local dimming, which uses clusters of tiny LED bulbs that can fully turn themselves on or off for more precise contrast during any scene or livestream. Other impressive numbers include a peak brightness of 3,000 nits (great news for FIFA fans trying to watch a game during the daytime) and a native 165Hz refresh rate (great news for gamers on a budget).

Best Frame TV deal Opens in a new window Credit: Samsung Samsung 55-inch The Frame Pro Neo QLED TV $1,267.99 at Amazon
$1,497.99 Save $230 + get a free Echo Show 11 Get Deal Why we like it

Samsung's latest Frame TVs just got their first discount during Prime Day and if that wasn't enough, Amazon is sweetening the deal. The new Frame TVs come with Neo QLEDs, a Micro HDMI port, and that signature art display.

But during Prime Day, Amazon is offering an even bigger discount. The Frame Pro is $230 off, its first discount, bringing it down to $1,297.99. That's 15% savings, but there's more. You'll also get a free Echo Show 11 with your purchase if you add it to your cart from the promo page. That's a $219.99 value, totally free.

This deal is available on both the Frame TV Pro and regular Frame TV.

Best Amazon TV deal Opens in a new window Credit: Amazon Amazon 65-inch Ember Artline 4K QLED Fire TV $799.99 at Amazon
$1,099.99 Save $300 with code SAVEFTV Get Deal Why we like it

It's not Prime Day without record-low prices on Amazon's own gadgets. The 65-inch Ember Artline TV, which was just released at the end of April, got its biggest discount ever right before the Prime Day festivities kicked off. Now that we're in the trenches of the sale, Amazon has knocked an extra $100 off for select Prime members. Click on "Redeem" under the Prime Day logo to score the extra savings or enter the code FTVSAVE at checkout to get this model for only $799.99.

Think of the Ember Artline as Amazon's dupe of The Frame. It's designed to look like a painting on the wall, with a matte screen, an assortment of frame options, and a gallery of 2,000+ free works of art. Basically, if you have The Frame taste, but you're on a bit tighter budget, this is the deal for you.

Deals on 43-inch TVs and underDeals on 50-inch to 55-inch TVsDeals on 65-inch TVs Deals on 75-inch to 77-inch TVsDeals on 85-inch TVs
Categories: IT General, Technology

PowerToys replaced tools I used to install on every Windows PC

How-To Geek - 4 hours 49 min ago

I've been using Raycast for Windows since shortly after the public beta launched last November, and I still think it's a good program. It gave Windows the kind of fast app launcher and command bar experience I'd been missing, especially when I wanted to open apps, jump into actions, or avoid digging through menus. For a while, it felt like one of those small utilities I'd automatically install on every Windows PC I used.

Categories: IT General, Technology

The Oura Ring 4 is at an all-time low price for Prime Day — save over $200

Mashable - 4 hours 52 min ago

SAVE OVER $200: As of June 24, the Mashable-tested Oura Ring 4 has dropped to a new low price of $214 at Amazon, with prices varying based on the size. That's a 38% discount from its usual $349 price.

Oura Ring 4 $214 at Amazon
$349 Save $135   Get Deal at Amazon Get Deal at Best Buy Get Deal at Target

We're officially into day two of Amazon's four-day-long Prime Day sale, and there's still plenty of exciting offers catching our attention. One of our favorite fitness trackers, the Oura Ring 4, has hit a new all-time low price at Amazon.

As of June 24, this popular smart ring is available for as little as $214 on Prime Day 2026. Normally it's listed with a full price of $349, so this deal offers significant savings.

Multiple Mashable reporters and editors have tested this model of the Oura Ring, and across the board, they've had very positive experiences. One of our reporters even wore this smart ring while training for and then running the New York City marathon. Our testers praise its abilities as both a fitness and sleep tracker, and there's a reason it's beloved by pro and amateur athletes alike.

Multiple members of the Mashable team have tested and loved the Oura smart ring. Credit: Joe Maldonado / Mashable SEE ALSO: Everything to know about Amazon Prime Day: Dates, competition, and the best deals to shop

If you want a tracker without a screen, the Oura Ring 4 is an easy choice. Powered by Smart Sensing technology, this stylish smart ring tracks a variety of health metrics right from your finger, including sleep, stress, activity, heart health, and even metrics specific to women's health. It also boasts a solid battery life that can last you up to eight days.

It's among our favorite fitness trackers and our favorite overall smart ring, though it's since been eclipsed by the new Oura Ring 5. After testing the ring, Mashable's Kimberly Gedeon wrote, "the Oura Ring 4 is a wellness powerhouse with a sleek design and cutting-edge AI that takes personalized health tracking to the next level."

This Prime Day deal won't last for long. Act fast to save on the Oura Ring 4 while it's still on sale at Amazon.

Pro tip: If you're not sure of your size, order the Oura Ring Sizing Kit. The kit is available for Prime members for just $8.49 with overnight delivery in many locations.

Want to learn more about getting the best out of your tech? Sign up for Mashable's Top Stories and Deals newsletters today.

Categories: IT General, Technology

Slate reveals pricing for its affordable electric pickup

Mashable - 4 hours 56 min ago

Remember Slate Auto, the minimalistic, made-in-America electric truck that went viral in 2025? Originally, the car was supposed to start at $20,000 after federal incentives.

Now, official price has been revealed and it's not exactly that, but it isn't too bad either.

SEE ALSO: BMW's new i3 is so hot, the company opened preorders months ahead of schedule

The official starting price for Slate Auto is $24,950, though that doesn't include a destination charge, taxes, and other potential fees. Those federal credits that Slate hoped would push the price below $20,000 no longer exist thanks to Donald Trump's "Big Beautiful Bill", so hoping the price would be so low was unrealistic, anyways.

For the price, you get the Blank Slate edition, which comes with a nice surprise: a slightly larger-than-announced 63kWh battery with 205 miles of EPA range. Other highlights include a single, rear-mounted 135kW motor with 181 hp, a 20-80 percent charge in 30 minutes on a DC fast charger, a 1,550lb max payload,and a towing capacity at around 2,000lb. The 0-60mph time is a flat eight seconds, and top speed is 90mph.

In terms of safety and comfort, you get traction control, electronic stability control, automatic emergency braking, forward collision warning, a backup camera, and remote keyless entry, among other amenities (see full specs on Slate's website).

The Slate Auto starts pretty basic, but you can add a bunch of goodies to it to make it unique. Credit: Slate

The car remains highly modular. You can choose between 100 color wraps with most costing an additional $499, and turn the Blank Slate variant into the Slate SUV variant which has a full roof (Fastback and an Open Air variants are also available). The pricing for those upgrades, however, hasn't been revealed yet.

While the price was expected, the big news here is the battery and the 205 miles of range, a pretty big increase from the originally announced 150 miles. Also, the car has an NCAS charging port, making it compatible with Tesla Supercharger network. The charging speed at 120kW is not the best out there but it's still plenty fast, especially on a battery of this size.

Slate said it received 180,000 reservations for the car so far, and deliveries start in the fourth quarter of the year.

Categories: IT General, Technology

Why this convertible remains the best budget sports car in 2026

How-To Geek - 5 hours 4 min ago

Sports cars have become increasingly complicated over the last decade. More power, more technology, and endless performance metrics have pushed many modern machines into territory that feels inaccessible, both financially and emotionally. As prices continue to climb, the idea of an affordable driver's car seems to be disappearing.

Categories: IT General, Technology

The best Prime Day AirPods deals — AirPods Max 2 have never been cheaper

Mashable - 5 hours 10 min ago
The best Prime Day deals on AirPods: Best AirPods deal Apple AirPods 4 $99 (save $30) Get Deal Best AirPods Pro Deal Apple AirPods Pro 3 $179 (save $70) Get Deal Best AirPods Max deal (and a new record-low price) Apple AirPods Max 2 $399 (save $150) Get Deal

Need a new pair of AirPods? You can always find Apple's earbuds and headphones on sale for cheaper than usual during Amazon's Prime Day event — not just on Amazon, but at competing retailers, too.

Prime Day 2026 is live now through June 26, and so far, the top AirPods deal involves the over-ear AirPods Max 2. They're currently marked down to a record-low price of $399 on Amazon, or a whopping $150 off. (They only just came out in April, mind you.) Amazon's inventory is starting to dwindle as we approach the midway point of Prime Day, but Walmart still has a few colorways in stock at the same price; it's running a sale of its own this week.

SEE ALSO: Amazon Prime Day is here: We found 75+ deals on Apple, Sony, Kindle, and Lego favorites

Meanwhile, the entry-level AirPods 4 and noise-cancelling AirPods Pro 3 are both on sale for up to $70 off this Prime Day. Neither model is matching its biggest discount on record, but given Apple's plans for price hikes in the near future, these are probably going to be their best deals for a while.

Read on for our rundown of the best Prime Day AirPods deals available. If you're a brand loyalist, be sure to check out our dedicated guide to the top Prime Day deals on all Apple products.

Best AirPods deal Opens in a new window Credit: Apple Apple AirPods 4 $99 at Amazon
$129 Save $30   Get Deal Why we like it

The vanilla AirPods 4 are our No. 1 Apple earbuds for budget buyers. In our testing, they sounded fantastic, fit comfortably, and worked seamlessly with other Apple devices. We saw them drop all the way down to $69 last Black Friday, but $99 is their best price so far in 2026. Save $30 at Amazon and Walmart. (PSA: Walmart also has pre-owned AirPods 4 on sale for just $65.)

The AirPods 4 are also available with ANC. That pair is on sale for $148.99 (normally $179) at Amazon, Walmart, and Costco. For reference, their record-low price is $99.

Read Mashable's full review of the AirPods 4 with ANC.

Best AirPods Pro deal Opens in a new window Credit: Apple Apple AirPods Pro 3 $179 at Amazon
$249 Save $70   Get Deal

The AirPods Pro 3 are our favorite AirPods across all price points, offering great ANC, an eight-hour battery life, plus extra fixings like a built-in heart rate monitor. They're also more water- and sweat-resistant than the regular AirPods 4, making them better for working out. They were only $169 on Amazon last week, but at the time of writing, they were sitting at $179 there. Walmart was price-matching them.

Read Mashable's full review of the AirPods Pro 3.

Best AirPods Max deal Opens in a new window Credit: Apple Apple AirPods Max 2 $399 at Amazon
$549 Save $150   Get Deal

Apple's newly updated headphones have better ANC than the original AirPods Max from 2021. They run on the same H2 chip as the AirPods Pro 3, so they support the same software features (such as Live Translation and Conversation Awareness). In one of the best and most unexpected Prime Day deals thus far, they're on sale for just $399 this week — a new all-time low. Amazon had them in stock at that price in midnight at the time of writing. They're price-matched at Walmart in blue, purple, and starlight.

Read Mashable's full review of the AirPods Max 2.

We will be regularly updating this guide with the best Prime Day AirPods deals, so keep checking back. You can also visit our Prime Day 2026 hub for all the latest updates and price drops.

Categories: IT General, Technology

I turned my old Android phone into a dashcam, and it was a mistake

How-To Geek - 5 hours 19 min ago

As our phones have become more powerful, they have evolved into much more than devices for making calls. However, just because our phones can do something does not mean they are the best tool for the job. As someone who turned an old Android phone into a dashcam, I can say that I regret doing it and will be switching back to a dedicated dash camera.

Categories: IT General, Technology

Talos: Scaling rare disease diagnosis with automated, iterative genomic reanalysis

Microsoft Research - 5 hours 19 min ago
At a glance
  • Talos is an open-source tool for automated, iterative reanalysis of genomic data in rare disease. It efficiently re-examines stored sequencing data as scientific knowledge evolves and flags variants with newly actionable evidence.
  • Talos is tuned for a low false-positive rate: across a validation set of nearly 1,100 patients, it recovered 90% of in-scope diagnoses while flagging only 1.3 candidate variants per patient for expert review. This is essential to making reanalysis sustainable at scale.
  • Deployed across a prospective cohort of almost 5,000 undiagnosed patients, Talos delivered 241 new diagnoses (5.1% additional yield). An average of only 32 days passed between supporting evidence becoming public and the resultant diagnosis.
  • On monthly iterative cycles, analysts only needed to review one new variant per 200 patients, demonstrating that frequent, systematic reanalysis can be run sustainably.
Why genome reanalysis matters

Genomic testing has transformed the diagnosis of rare disease, but even with this advancement, more than half of patients remain undiagnosed after their first test. This is because our knowledge of the genome is still incomplete. Researchers are learning more every day about the function of specific genes and how they relate to disease.

However, unlike most diagnostic investigations, genomic data has a unique property: it can be stored and reexamined indefinitely. Because our understanding of the genome improves constantly, simply rerunning the analysis later can yield a diagnosis that was impossible to make the first time. This is because there are hundreds of new gene–disease associations and thousands of new variant classifications reported every year.

Reanalysis of the genomes of undiagnosed patients is the solution; a meta-analysis of nearly 9,500 undiagnosed patients found that reanalysis lifted diagnostic yield by about 10% over roughly two years. However, the problem is that reanalysis today is overwhelmingly manual. It depends on motivated clinicians, scarce laboratory staff, and inconsistent reimbursement, so the vast majority of stored genomes are never revisited and the data keep accumulating. Automation has long been proposed as the answer, but the developers of automated machinery must navigate hard trade-offs between sensitivity, specificity, how many candidate variants a human must review, and how often the analysis is rerun.

Talos (opens in new tab), developed through a collaboration spanning the Centre for Population Genomics, Australian Genomics, the Broad Institute, and Microsoft, was built to resolve those trade-offs and to demonstrate, at international scale, that systematic reanalysis is both feasible and valuable. We have recently published a journal article (opens in new tab) detailing how Talos functions and evaluating its performance on multiple rare disease cohorts.

How Talos works

Talos re-interprets a patient’s existing variant calls against the latest community knowledge each time it runs. It draws on two continuously updated public resources: PanelApp Australia (opens in new tab) for gene–disease relationships and modes of inheritance, and ClinVar (opens in new tab) for variant-level pathogenicity. It then applies a variant-prioritization algorithm designed to surface variants most likely to meet ACMG/AMP criteria for clinical reporting.

Figure 1 – Talos overview. Talos operates in multiple stages, first collecting unchanging information about genetic variants and the patients who possess them, then applying up to date knowledge to filter and prioritize variants that are likely to be clinically relevant, then finally surfacing those variants to clinicians alongside supporting evidence. 

The pipeline uses newly discovered information to tag and filter variants, then refines the candidate set using family structure (for example, mode of inheritance and de novo status) and, when available, the patient’s phenotype. Talos can be used to interpret single-nucleotide variants, small insertions/deletions, copy number variants, and large structural variants from exome or genome data.

Two design choices distinguish Talos. First, it is deliberately conservative, optimized to return a small set of high confidence variants rather than a long ranked list, because in real-world genomic reanalysis the limiting factor is human review time, not algorithmic recall. Second, on repeat runs, Talos returns only variants whose supporting evidence has changed since the previous cycle, allowing clinicians to focus exclusively on findings that aregenuinely new.

Validated against expert manual analysis

We benchmarked Talos on two independent cohorts that had already undergone careful manual analysis: the Australian Acute Care Genomics (ACG) cohort of critically ill infants and children, and the U.S.-based Rare Genomes Project (RGP) cohort of families with prior uninformative testing. This included 1,089 probands in total.

On ACG trios, Talos recovered 90% of in-scope diagnoses while returning a median of just 1.3 candidate variants per family. The diagnoses it missed were largely a direct consequence of its conservative strategy, for example, recessive variants lacking ClinVar support that human analysts had classified using trans configuration or functional studies.

Crucially, Talos held the same operating point on the very different RGP cohort, agroup of families who had previously had uninformative clinical testing, with probands ranging up to 82 years of age. On RGP trios, it recovered 87% of in-scope diagnoses (47 of 54) at a median of 1.3 candidate variants per trio, showing generalizability across cohorts.

We then benchmarked head-to-head against Exomiser, a widely used prioritization tool. Talos matched its overall sensitivity for small variants, but at a very different operating point: Exomiser ranks and returns a broad list, while Talos returns a short, highly specific one. In a paired comparison, the two tools were statistically indistinguishable when all of Exomiser’s ranked variants were reviewed, but Talos came out significantly ahead once review was limited to a realistic budget—the top five (p = 0.017) or top one (p < 0.0001) ranked variants. Notably, the two tools surfaced different variants, so they are complementary and should ideally be used together in diagnostic workflows.

PODCAST SERIES

AI Testing and Evaluation: Learnings from Science and Industry

Discover how Microsoft is learning from other domains to advance evaluation and testing as a pillar of AI governance.

Listen now Opens in a new tab Deployed on an international scale

The experiment we were most excited about was a tested-but-undiagnosed cohort of 4,735 individuals, drawn from Australian Genomics research studies and a single diagnostic laboratory. Most patients were singletons with neurodevelopmental, cardiac, renal, and/or neurological indications.

Talos produced 241 new diagnoses in 238 individuals—a 5.1% additional yield, with every single likely-causative variant subsequently confirmed as pathogenic or likely pathogenic by accredited labs.

The sources of those diagnoses illustrate why reanalysis is such a powerful paradigm:

  • 32% came from new gene–disease relationships discovered since the original test,
  • 22% came from new variant-level evidence (reclassifications), and
  • 45% came from improved filtering and analysis—including variant types such as CNVs and structural variants not examined originally, phenotype filters that had been set too narrowly, and other sources.

Yield was consistent across clinical areas (roughly 5–6% for neurodevelopmental, cardiac, and renal indications) but the reasons differed: new gene associations and CNVs dominated neurodevelopmental diagnoses, while variant reclassification drove most cardiac ones. Genome data outperformed exome (6.1% vs 4.8%), partly by reaching non-coding diagnoses such as RNU4-2 and a deep-intronic MRPL39 variant. A recurring theme was the lag in conventional knowledge bases: 59% of the new gene–disease diagnoses were not yet curated in OMIM at the time of reanalysis, underscoring the value of drawing on a rapidly updated resource like PanelApp Australia.

From a one-off event to a continuous program

We then ran Talos for 29 monthly iterative cycles. Most diagnoses (92%) came on a cohort’s first pass, but the iterative design proved its value on two fronts. First, it demonstrated the scalability of ongoing reanalysis: because later cycles return only newly actionable evidence, they surfaced an average of just one variant per 200 cases over the program. Second, it showed how quickly we can move from scientific discovery to diagnosis: on average just 32 days passed between new knowledge appearing in a public database and a patient receiving a diagnosis, with the fastest case turning around in a single day. Figure 2 provides timelines for three example patients showing how continual reanalysis can bring answers to families within weeks of new scientific findings. The whole pipeline is cheap enough to run continuously: annotating 1,000 genomes cost about $11, and a monthly reanalysis pass ran for a few cents per cohort.

Figure 2 – Diagnostic odyssey for three example patients. Each patient spent years after genetic sequencing waiting for a diagnosis. For Patient 1, the scientific discovery enabling their diagnosis happened one month after their testing, but no diagnosis was made until the first time their genetic data was reanalyzed using Talos. For patients 2 and 3, diagnoses were made within a month of the relevant scientific findings because the patients were already in the reanalysis pipeline.  Looking ahead

Talos reframes genomic reanalysis from a rare, labor-intensive event into a continuous, automated program that can keep pace with the science. By optimizing for specificity, it respects the real bottleneck of expert reviewer time, and by drawing on openly shared, frequently updated resources like PanelApp Australia and ClinVar, it turns the global community’s accumulating knowledge into diagnoses for individual patients, often within weeks.

We believe we’ve established a foundational capability, and we’re excited to see how the community builds on it. In particular, as more advanced AI models for understanding and predicting the consequences of genetic variation become available, we’re looking forward to leveraging them in the reanalysis of unsolved rare disease cases.

Talos is open source and straightforward to deploy in cloud environments like Azure. Our results offer a practical blueprint for health systems aiming to deliver frequent, scalable reanalysis to the many patients still searching for diagnoses.

GitHub Nature Publication Opens in a new tab

The post Talos: Scaling rare disease diagnosis with automated, iterative genomic reanalysis appeared first on Microsoft Research.

Categories: Microsoft

Regularly $2,590, the ASUS ROG Strix G16 gaming laptop is over $400 off on Prime Day

Mashable - 5 hours 19 min ago

SAVE $490: As of June 24, the ASUS ROG Strix G16 (2025) is down to $2,099.99 at Amazon. That’s $490.01 off a high-end gaming laptop built for serious gaming and heavy workloads.

Opens in a new window Credit: ASUS ASUS ROG Strix G16 (2025) $2,099.99 at Amazon
$2,590 Save $490.01   Get Deal

Prime Day is officially here, and if you've been waiting for the right moment to upgrade your gaming laptop, this might be it. Amazon has cut the ASUS ROG Strix G16 (2025) to $2,099.99, knocking nearly $500 off the regular price and bringing the high-performance gaming laptop down to its lowest price this year.

This is a high-end gaming laptop built for people who want serious speed without waiting around for things to load. It runs on Intel’s Core Ultra 9 processor paired with NVIDIA’s RTX 5070 Ti graphics, which basically means it can handle demanding games, creative work, and heavy multitasking without slowing down. You also get 32GB of memory and a 1TB solid-state drive, so apps open quickly, and there’s plenty of space for a full game library.

On the experience side, the 16-inch display is designed for fast, smooth gameplay, which helps keep motion clear in fast-moving games. It also has an advanced cooling system designed to maintain steady performance during long gaming sessions instead of throttling under pressure.

The RGB lighting is mostly for looks and customization, but you can switch it off or tone it down if you want a more simple, work-friendly setup.

Grab the ASUS ROG Strix G16 (2025) on Amazon before your laptop starts charging emotional damage fees.

Our Best Editor-Vetted Prime Day Deals Right Now

Apple AirPods Pro 3 Noise Cancelling Heart Rate Wireless Earbuds — $179.00 (List Price $249.00)

Apple AirPods 4 Wireless Earbuds With Active Noise Cancellation — $148.99 (List Price $179.00)

Apple iPad 11" 128GB Wi-Fi Retina Tablet (Silver, 2025 Release) — $299.00 (List Price $349.00)

Apple Watch Series 11 (GPS, 42mm, S/M Black Sport Band) — $279.00 (List Price $399.00)

Sony WH-1000XM6 Wireless Noise Cancelling Over-Ear Headphones — $378.00 (List Price $459.99)

55" Amazon Ember 4-Series 4K HDR10+ Smart Fire TV (2025 Model) — $279.95 (List Price $459.99)

Fire TV Stick 4K Plus Streaming Player With Remote (2025 Model) — $24.99 (List Price $49.99)

Meta Quest 3S 128GB With 3-Month Trial of Meta Horizon+ — $296.79 (List Price $349.99)

Categories: IT General, Technology

7 Prime Day iPhone deals to get ahead of the price increase, including a free iPhone from T-Mobile

Mashable - 5 hours 26 min ago
The best Prime Day iPhone deals at a glance: Best iPhone 17 Pro deal Apple iPhone 17 Pro (256GB) Free with Experience More or Experience Beyond at T-Mobile (save $1,099.99) Get Deal Best iPhone Air deal Apple iPhone Air (256GB) $839.99 at Best Buy (save $160) Get Deal Best budget iPhone deal Apple iPhone 16e (128GB) $489.99 at Best Buy (save $110) Get Deal Best renewed iPhone 17 Pro deal Apple iPhone 17 Pro 512GB (Renewed Premium) 999.99 at Amazon (save $249) Get Deal

Amazon Prime Day has kicked off earlier than ever this year. Amazon must know we're all looking for a good deal in an economy with ever-rising prices. If you're on team iPhone, those price increases aren't expected to chill out anytime soon. Tim Cook just announced iPhone price hikes are "unavoidable," citing a chip problem that doesn't seem to have a solution.

Our recommendation is to shop for deals as soon as possible if you need an iPhone upgrade. Amazon doesn't currently have any new iPhone deals, but we're seeing some great options elsewhere, including Best Buy and T-Mobile.

Here's where to snag the best iPhone deals before the price increase. If you're shopping for other Apple devices like AirPods or a MacBook, check out the best Apple deals this Prime Day.

Best iPhone 17 deal Opens in a new window Credit: Apple Apple iPhone 17 Pro $0 at T-Mobile
$1,099.99 Save $1,099.99   Get Deal Why we like it

It doesn't get better than free. With no trade-in required, T-Mobile has an excellent deal if you're eyeing the new iPhone 17 Pro. It's free! Of course, there's a slight catch, but it's not terrible. All you need to do is sign on to a T-Mobile Experience More or Experience Beyond plan for 24 months. Over these consecutive months, T-Mobile applies a promo credit to bring the price of the phone to zero. Plus, the Cosmic Orange colorway makes a statement.

Best iPhone Air deal Opens in a new window Credit: Apple Apple iPhone Air (256GB) $839.99 at Best Buy
$999.99 Save $160   Get Deal Why we like it

Read Mashable's full review of the iPhone Air.

For those who want slim but durable, the new iPhone Air is ideal. It's Apple's thinnest-ever iPhone at 5.6mm while having an ultralight titanium frame. Battery life measures about 27 hours and it's compatible with eSIMs if you'll be traveling soon.

Shop Best Buy this Prime Day to snag the 256GB iPhone Air while it's on sale for $839.99.

Best budget iPhone deal Opens in a new window Credit: Apple Apple iPhone 16e (128GB) $489.99 at Best Buy
$599.99 Save $110   Get Deal Why we like it

Your old iPhone no longer holds a charge but you're not looking to spend much to get a new model. If that's the case, consider the Prime Day sale on the iPhone 16e for $489.99. You'll be getting 128GB storage, a 6.1-inch display, and the A18 chip. While this isn't the newest model, it's only one generation behind.

Best Renewed iPhone 17 Pro deal Opens in a new window Credit: Apple Apple iPhone 17 Pro 512GB (Renewed Premium) $999.99 at Amazon
$1,249 Save $249.01   Get Deal Why we like it

If you’re okay skipping the brand-new box experience, this is one of the easiest ways to save on a higher-storage iPhone 17 Pro. The 512GB Renewed Premium iPhone 17 Pro is down to $999.99 on Amazon, cutting $249 off the usual price and bringing a top-tier storage option below the $1,000 mark.

Because it’s listed as Renewed Premium, it also comes with stricter quality checks than standard refurbished models, so it’s closer to a “like-new” experience while still costing significantly less.

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